Pre_GI: BLASTP Hits

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Query: NC_009089:1329826:1333408 Clostridium difficile 630, complete genome

Start: 1333408, End: 1333779, Length: 372

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017179:1197763:120134512013451201716372Clostridium difficile BI1, complete genomelactoylglutathione lyase2e-67253
NC_013315:1187986:119156811915681191939372Clostridium difficile CD196 chromosome, complete genomelactoylglutathione lyase2e-67253
NC_013316:1186156:118918411891841189555372Clostridium difficile R20291, complete genomelactoylglutathione lyase2e-67253
NC_013520:1559000:157732215773221577696375Veillonella parvula DSM 2008, complete genomeGlyoxalase/bleomycin resistance protein/dioxygenase5e-40162
NC_003454:983681:987571987571987942372Fusobacterium nucleatum subsp. nucleatum ATCC 25586, completeLactoylglutathione lyase4e-39159
NC_009614:3714770:373110037311003731477378Bacteroides vulgatus ATCC 8482 chromosome, complete genomelactoylglutathione lyase4e-37152
NC_014363:1344768:134615913461591346527369Olsenella uli DSM 7084 chromosome, complete genomeGlyoxalase/bleomycin resistance protein/dioxygenase5e-22102
NC_021175:845370:862275862275862661387Streptococcus oligofermentans AS 1.3089, complete genomelactoylglutathione lyase2e-1271.6
NC_002516:776787:782570782570782965396Pseudomonas aeruginosa PAO1, complete genomelactoylglutathione lyase8e-1165.9
NC_008820:2422000:244082324408232441224402Prochlorococcus marinus str. MIT 9303, complete genomeLactoylglutathione lyase3e-1063.9
NC_005071:2180000:219800721980072198408402Prochlorococcus marinus str. MIT 9313, complete genomeGlyoxalase/Bleomycin resistance protein/Dioxygenase superfami...5e-1063.2
NC_007516:2277910:228069322806932281091399Synechococcus sp. CC9605, complete genomeGlyoxalase I6e-1062.8
NC_015942:2316354:233184823318482332231384Acidithiobacillus ferrivorans SS3 chromosome, complete genomelactoylglutathione lyase2e-0961.6
NC_010172:480000:487928487928488368441Methylobacterium extorquens PA1, complete genomeGlyoxalase/bleomycin resistance protein/dioxygenase2e-0961.2
NC_018012:3300000:331428533142853314680396Thiocystis violascens DSM 198 chromosome, complete genomelactoylglutathione lyase2e-0961.2
NC_009482:2051890:205486920548692055273405Synechococcus sp. RCC307 chromosome, complete genomelactoylglutathione lyase1e-0858.9
NC_013158:200424:239271239271240029759Halorhabdus utahensis DSM 12940, complete genomeGlyoxalase/bleomycin resistance protein/dioxygenase1e-0858.5
NC_010125:2884762:294515229451522945589438Gluconacetobacter diazotrophicus PAl 5, complete genomeputative lactoylglutathione lyase5e-0856.2
NC_007484:3035068:303744330374433037826384Nitrosococcus oceani ATCC 19707, complete genomeGlyoxalase I6e-0856.2
NC_010003:528855:542684542684543091408Petrotoga mobilis SJ95, complete genomeGlyoxalase/bleomycin resistance protein/dioxygenase1e-0755.5
NC_014834:3130715:318404331840433184492450Rhodopseudomonas palustris DX-1 chromosome, complete genomeglyoxalase/bleomycin resistance protein/dioxygenase2e-0754.7
NC_008380:2210649:221444222144422214882441Rhizobium leguminosarum bv. viciae 3841, complete genomeputative glyoxalase3e-0753.9
NC_014375:217612:235278235278235718441Brevundimonas subvibrioides ATCC 15264 chromosome, complete genomeGlyoxalase/bleomycin resistance protein/dioxygenase4e-0753.5
NC_020911:3076791:308123030812303081622393Octadecabacter antarcticus 307, complete genomeputative lactoylglutathione lyase GloA5e-0753.1
NC_005296:2860000:286348728634872863936450Rhodopseudomonas palustris CGA009, complete genomeputative lactoylglutathione lyase6e-0752.8
NC_013967:827150:830369830369831148780Haloferax volcanii DS2 chromosome, complete genomelactoylglutathione lyase4e-0650.1