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Query: NC_009089:1329826:1332168 Clostridium difficile 630, complete genome

Start: 1332168, End: 1332380, Length: 213

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017179:1197763:120010512001051200317213Clostridium difficile BI1, complete genomeheavy-metal binding protein1e-31134
NC_013315:1187986:119032811903281190540213Clostridium difficile CD196 chromosome, complete genomeheavy-metal binding protein1e-31134
NC_013316:1186156:118794411879441188156213Clostridium difficile R20291, complete genomeputative heavy-metal binding protein1e-31134
NC_007907:5104476:511809451180945118309216Desulfitobacterium hafniense Y51, complete genomehypothetical protein8e-1165.9
NC_015425:1687050:169251616925161692728213Clostridium botulinum BKT015925 chromosome, complete genomecopper ion binding protein1e-0858.5
NC_021182:4022894:402476740247674024976210Clostridium pasteurianum BC1, complete genomecopper chaperone9e-0855.5
NC_008593:1513107:151650815165081516720213Clostridium novyi NT, complete genomecopper ion binding protein1e-0755.1
NC_017068:1852708:1852708185270818552722565Selenomonas ruminantium subsp. lactilytica TAM6421, completeputative copper-exporting P-type ATPase A8e-0752.8