Pre_GI: BLASTP Hits

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Query: NC_009089:1329826:1329231 Clostridium difficile 630, complete genome

Start: 1329231, End: 1329833, Length: 603

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017179:1197763:119716811971681197770603Clostridium difficile BI1, complete genomedephospho-CoA kinase1e-90332
NC_013315:1187986:118739111873911187993603Clostridium difficile CD196 chromosome, complete genomedephospho-CoA kinase1e-90332
NC_011772:4487378:451472645147264515328603Bacillus cereus G9842, complete genomedephospho-CoA kinase2e-28125
NC_013943:2547966:254796625479662548583618Denitrovibrio acetiphilus DSM 12809 chromosome, complete genomedephospho-CoA kinase2e-24112
NC_011901:837085:843796843796844401606Thioalkalivibrio sulfidophilus HL-EbGr7 chromosome, completeDephospho-CoA kinase4e-22104
NC_016582:9459566:946315394631539463770618Streptomyces bingchenggensis BCW-1 chromosome, complete genomedephospho-CoA kinase1e-21103
NC_010159:1071937:107132010713201071940621Yersinia pestis Angola, complete genomedephospho-CoA kinase1e-21103
NC_012914:1824955:182436218243621824958597Paenibacillus sp. JDR-2, complete genomedephospho-CoA kinase8e-22103
NC_021182:2059143:208123020812302081826597Clostridium pasteurianum BC1, complete genomedephospho-CoA kinase5e-22103
NC_005125:2269343:228582422858242286441618Gloeobacter violaceus PCC 7421, complete genomeprobable dephospho-CoA kinase2e-21102
NC_011661:906583:910673910673911278606Dictyoglomus turgidum DSM 6724, complete genomedephospho-CoA kinase3e-21101
NC_012438:1600534:160053416005341601124591Sulfurihydrogenibium azorense Az-Fu1 chromosome, complete genomedephospho-CoA kinase1e-2099.8
NC_021066:3201500:322382432238243224444621Raoultella ornithinolytica B6, complete genomedephospho-CoA kinase4e-2097.8
NC_007508:3835000:384340038434003844011612Xanthomonas campestris pv. vesicatoria str. 85-10, complete genomedephospho-CoA kinase4e-1994.7
NC_003919:3812778:382254738225473823155609Xanthomonas axonopodis pv. citri str. 306, complete genomedephospho-CoA kinase4e-1994.4
NC_010718:1959517:198065919806591981249591Natranaerobius thermophilus JW/NM-WN-LF, complete genomedephospho-CoA kinase1e-1893.2
NC_014039:869826:880475880475881170696Propionibacterium acnes SK137 chromosome, complete genomedephospho-CoA kinase1e-1892.8
NC_016516:834260:844969844969845676708Propionibacterium acnes TypeIA2 P.acn33 chromosome, completedephospho-CoA kinase2e-1892.4
NC_016512:843938:853546853546854253708Propionibacterium acnes TypeIA2 P.acn17 chromosome, completedephospho-CoA kinase2e-1892.4
NC_016511:844500:854170854170854877708Propionibacterium acnes TypeIA2 P.acn31 chromosome, completedephospho-CoA kinase2e-1892.4
NC_009714:74500:907759077591380606Campylobacter hominis ATCC BAA-381, complete genomedephospho-CoA kinase2e-1892
NC_006085:854500:864204864204864899696Propionibacterium acnes KPA171202, complete genomedephospho-CoA kinase4e-1891.3
NC_014643:1986440:203366620336662034496831Rothia dentocariosa ATCC 17931 chromosome, complete genomedephospho-CoA kinase6e-1890.5
NC_011663:4579777:459745445974544598071618Shewanella baltica OS223 chromosome, complete genomedephospho-CoA kinase8e-1890.1
NC_008321:458811:461998461998462615618Shewanella sp. MR-4, complete genomedephospho-CoA kinase8e-1890.1
NC_009665:4675289:469271046927104693327618Shewanella baltica OS185 chromosome, complete genomedephospho-CoA kinase1e-1789.7
NC_015144:693958:695244695244695852609Weeksella virosa DSM 16922 chromosome, complete genomeDephospho-CoA kinase2e-1789
NC_013961:2932348:295561829556182956229612Erwinia amylovora, complete genomeDephospho-CoA kinase2e-1789
NC_013939:295220:314368314368315015648Deferribacter desulfuricans SSM1, complete genomedephospho-CoA kinase4e-1787.8
NC_018868:3943088:394834539483453948938594Simiduia agarivorans SA1 = DSM 21679 chromosome, complete genomedephospho-CoA kinase5e-1787.4
NC_017267:3612682:362123336212333621841609Xanthomonas oryzae pv. oryzicola BLS256 chromosome, completedephospho-CoA kinase1e-1686.7
NC_014935:31020:316163161632212597Nitratifractor saLSUginis DSM 16511 chromosome, complete genomedephospho-CoA kinase1e-1686.3
NC_007645:5397526:542380354238035424429627Hahella chejuensis KCTC 2396, complete genomedephospho-CoA kinase1e-1686.3
NC_008262:2150944:216562621656262166225600Clostridium perfringens SM101, complete genomedephospho-CoA kinase1e-1686.3
NC_003366:2266757:228253322825332283132600Clostridium perfringens str. 13, complete genomedephospho-CoA kinase1e-1686.3
NC_008261:2481500:249636624963662496965600Clostridium perfringens ATCC 13124, complete genomedephospho-CoA kinase2e-1685.9
NC_010717:1469911:148680814868081487416609Xanthomonas oryzae pv. oryzae PXO99A, complete genomedephospho-CoA kinase2e-1685.9
NC_006834:1602994:162094016209401621548609Xanthomonas oryzae pv. oryzae KACC10331, complete genomehypothetical protein2e-1685.9
NC_007705:1583373:160311116031111603719609Xanthomonas oryzae pv. oryzae MAFF 311018, complete genomehypothetical protein2e-1685.9
NC_015410:969526:973934973934974542609Pseudomonas mendocina NK-01 chromosome, complete genomedephospho-CoA kinase2e-1685.5
NC_010322:768849:770668770668771291624Pseudomonas putida GB-1 chromosome, complete genomedephospho-CoA kinase3e-1684.7
NC_020829:1068438:107067210706721071280609Pseudomonas denitrificans ATCC 13867, complete genomedephospho-CoA kinase4e-1684.7
NC_009439:860571:867899867899868507609Pseudomonas mendocina ymp, complete genomedephospho-CoA kinase4e-1684.7
NC_007912:1111093:111627811162781116889612Saccharophagus degradans 2-40, complete genomePhosphoribosylglycinamide formyltransferase5e-1684.3
NC_015733:715947:715947715947716570624Pseudomonas putida S16 chromosome, complete genomedephospho-CoA kinase7e-1683.6
NC_012004:470492:488114488114488701588Streptococcus uberis 0140J, complete genomedephospho-CoA kinase1e-1582.8
NC_013530:1649214:165385316538531654491639Xylanimonas cellulosilytica DSM 15894, complete genomedephospho-CoA kinase2e-1582.4
NC_009482:2051890:206618420661842066825642Synechococcus sp. RCC307 chromosome, complete genomedephospho-CoA kinase2e-1582
NC_009512:755658:757265757265757888624Pseudomonas putida F1, complete genomedephospho-CoA kinase2e-1582
NC_002947:737924:737924737924738547624Pseudomonas putida KT2440, complete genomedephospho-CoA kinase2e-1582
NC_018080:5070687:508456750845675085178612Pseudomonas aeruginosa DK2 chromosome, complete genomedephospho-CoA kinase6e-1580.9
NC_015740:1017000:102801110280111028619609Pseudomonas stutzeri ATCC 17588 = LMG 11199 chromosome, completedephospho-CoA kinase6e-1580.9
NC_010501:4989455:501042350104235011046624Pseudomonas putida W619, complete genomedephospho-CoA kinase5e-1580.9
NC_009656:5297000:531330453133045313915612Pseudomonas aeruginosa PA7 chromosome, complete genomedephospho-CoA kinase5e-1580.9
NC_017986:3407913:341020134102013410824624Pseudomonas putida ND6 chromosome, complete genomedephospho-CoA kinase9e-1580.1
NC_014830:1871135:1891444189144418926461203Intrasporangium calvum DSM 43043 chromosome, complete genomedephospho-CoA kinase2e-1479
NC_014910:966761:970448970448971062615Alicycliphilus denitrificans BC chromosome, complete genomedephospho-CoA kinase2e-1479
NC_015422:910292:911826911826912440615Alicycliphilus denitrificans K601 chromosome, complete genomedephospho-CoA kinase2e-1479
NC_008343:2389710:238971023897102390351642Granulibacter bethesdensis CGDNIH1, complete genomedephospho-CoA kinase2e-1479
NC_010995:3197686:321437632143763214993618Cellvibrio japonicus Ueda107, complete genomedephospho-CoA kinase2e-1479
NC_017192:159047:176533176533177123591Arcobacter sp. L, complete genomedephospho-CoA kinase3e-1478.6
NC_009434:1156834:116830811683081169111804Pseudomonas stutzeri A1501, complete genomedephospho-CoA kinase3e-1478.2
NC_017271:3641705:365430936543093654932624Xanthomonas campestris pv. raphani 756C chromosome, completedephospho-CoA kinase3e-1478.2
NC_004369:1525787:152999915299991530601603Corynebacterium efficiens YS-314, complete genomedephospho-CoA kinase3e-1478.2
NC_008027:4953432:497080949708094971432624Pseudomonas entomophila L48, complete genomedephosphocoenzyme A kinase1e-1376.3
NC_010688:1192410:124403012440301244653624Xanthomonas campestris pv. campestris, complete genomehypothetical protein1e-1376.3
NC_003902:3666544:367679836767983677421624Xanthomonas campestris pv. campestris str. ATCC 33913, completedephospho-CoA kinase1e-1376.3
NC_007086:1224867:127095712709571271580624Xanthomonas campestris pv. campestris str. 8004, complete genomedephospho-CoA kinase1e-1376.3
NC_009074:3409849:343745434374543438065612Burkholderia pseudomallei 668 chromosome I, complete sequencedephospho-CoA kinase4e-1374.7
NC_010003:1126800:113650811365081137089582Petrotoga mobilis SJ95, complete genomedephospho-CoA kinase4e-1374.7
NC_015913:293980:293980293980294573594Candidatus Arthromitus sp. SFB-mouse-Japan, complete genomedephospho-CoA kinase4e-1374.7
NC_015556:4074367:409580440958044096412609Pseudomonas fulva 12-X chromosome, complete genomeDephospho-CoA kinase7e-1373.9
NC_014924:725380:729266729266729889624Pseudoxanthomonas suwonensis 11-1 chromosome, complete genomedephospho-CoA kinase9e-1373.6
NC_010804:450130:450130450130450738609Burkholderia multivorans ATCC 17616 chromosome 1, completedephospho-CoA kinase9e-1373.6
NC_010084:3051355:307403530740353074643609Burkholderia multivorans ATCC 17616 chromosome 1, completedephospho-CoA kinase9e-1373.6
NC_007516:2277910:229696422969642297587624Synechococcus sp. CC9605, complete genomeDephospho-CoA kinase1e-1273.2
NC_016012:236012:256021256021256614594Candidatus Arthromitus sp. SFB-rat-Yit, complete genomedephospho-CoA kinase1e-1273.2
NC_011565:190406:201912201912202496585Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2,dephospho-CoA kinase3e-1271.6
NC_016632:230500:258781258781259410630Serratia symbiotica str. 'Cinara cedri' chromosome, completedephosphocoenzyme A kinase4e-1271.2
NC_012039:53497:534975349754078582Campylobacter lari RM2100, complete genomedephospho-CoA kinase1e-1169.7
NC_010677:456277:457578457578458192615Francisella tularensis subsp. mediasiatica FSC147, complete genomedephospho-CoA kinase2e-1168.9
NC_009663:2500186:250447825044782505071594Sulfurovum sp. NBC37-1, complete genomedephospho-CoA kinase3e-1168.6
NC_009465:29735:637526375264357606Candidatus Vesicomyosocius okutanii HA, complete genomedephospho-CoA kinase5e-1167.8
NC_009749:289695:293031293031293645615Francisella tularensis subsp. holarctica FTA, complete genomedephospho-CoA kinase6e-1167.4
NC_008601:1560482:159237815923781592992615Francisella tularensis subsp. novicida U112, complete genomedephospho-CoA kinase6e-1167.4
NC_008245:1525877:154031015403101540924615Francisella tularensis subsp. tularensis FSC 198, complete genomeDephospho-CoA kinase6e-1167.4
NC_007880:290059:293395293395294009615Francisella tularensis subsp. holarctica, complete genomeDephospho-CoA kinase6e-1167.4
NC_006570:1526071:154050415405041541118615Francisella tularensis subsp. tularensis Schu 4, complete genomeDephospho-CoA kinase6e-1167.4
NC_008369:291640:294976294976295590615Francisella tularensis subsp. holarctica OSU18, complete genomedephospho-CoA kinase6e-1167.4
NC_016933:1601821:161625416162541616868615Francisella tularensis TIGB03 chromosome, complete genomedephospho-CoA kinase6e-1167.4
NC_016937:1525914:154034715403471540961615Francisella tularensis subsp. tularensis TI0902 chromosome,dephospho-CoA kinase6e-1167.4
NC_009257:775538:782069782069782683615Francisella tularensis subsp. tularensis WY96-3418 chromosome,dephospho-CoA kinase6e-1167.4
NC_014655:17641:333743337433970597Leadbetterella byssophila DSM 17132 chromosome, complete genomedephospho-CoA kinase2e-1065.9
NC_014109:326500:333231333231333875645Candidatus Riesia pediculicola USDA chromosome, complete genomedephospho-CoA kinase1e-0962.8
NC_015947:3539472:354817035481703548781612Burkholderia sp. JV3 chromosome, complete genomeDephospho-CoA kinase4e-0961.2
NC_013171:1420135:141954614195461420148603Anaerococcus prevotii DSM 20548, complete genomedephospho-CoA kinase1e-0860.1
NC_008782:841134:844891844891845514624Acidovorax sp. JS42, complete genomedephospho-CoA kinase1e-0859.7
NC_009952:3596399:363135236313523631948597Dinoroseobacter shibae DFL 12, complete genomedephospho-CoA kinase1e-0859.3
NC_011992:773905:793032793032793625594Acidovorax ebreus TPSY, complete genomedephospho-CoA kinase2e-0859.3
NC_008740:2989856:300612930061293006746618Marinobacter aquaeolei VT8, complete genomedephospho-CoA kinase2e-0858.9
NC_019815:679592:699541699541700143603Candidatus Kinetoplastibacterium crithidii (ex Angomonas deaneidephospho-CoA kinase3e-0858.2
NC_007802:179780:186433186433187017585Jannaschia sp. CCS1, complete genomeDephospho-CoA kinase6e-0857.4
NC_011071:3544450:356177335617733562384612Stenotrophomonas maltophilia R551-3, complete genomedephospho-CoA kinase1e-0756.2
NC_018604:2053585:205358520535852054202618Brachyspira pilosicoli WesB complete genomedephospho-CoA kinase4e-0754.7
NC_013714:1028569:102794010279401028572633Bifidobacterium dentium Bd1, complete genomeDephospho-CoA kinase7e-0753.9
NC_010483:1441614:145414214541421454684543Thermotoga sp. RQ2, complete genomedephospho-CoA kinase1e-0652.8