Pre_GI: BLASTP Hits

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Query: NC_008593:2527064:1903 Clostridium novyi NT, complete genome

Start: 1903, End: 2532, Length: 630

Host Lineage: Clostridium novyi; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain (NT) was created so that it lacks the lethal toxin. Injection of spores of this organism into mice harboring tumors resulted in an increased immune response and destruction of the tumor tissue in a method known as COBALT (combination bacteriolytic therapy) when the spores along with chemotherapeutic agents or radiation are co-administered. The anaerobic bacteria preferentially target hypoxic cancer tissue and stimulate immune responses to that tissue. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. Clostridium novyi is an anaerobic bacterium found in soil, aquatic sediments, and intestinal tract of both animals and humans. Some types produce lethal toxins.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_004557:32094:544915449155138648Clostridium tetani E88, complete genomeconserved protein, JAG-family3e-67254
NC_016627:4871875:489516048951604895780621Clostridium clariflavum DSM 19732 chromosome, complete genomeputative RNA-binding protein1e-49196
NC_011898:4044500:406594340659434066575633Clostridium cellulolyticum H10, complete genomesingle-stranded nucleic acid binding R3H domain protein8e-45180
NC_014220:2398334:240331324033132403942630Syntrophothermus lipocalidus DSM 12680 chromosome, complete genomesingle-stranded nucleic acid binding R3H domain protein4e-44177
NC_020134:2948000:297169629716962972334639Clostridium stercorarium subsp. stercorarium DSM 8532, completeprotein Jag2e-42171
NC_015519:2739347:275768227576822758296615Tepidanaerobacter sp. Re1 chromosome, complete genomesingle-stranded nucleic acid binding R3H domain-containing protein3e-41167
NC_014392:2513529:252522525252252525851627Caldicellulosiruptor obsidiansis OB47 chromosome, complete genomesingle-stranded nucleic acid binding R3H domain-containing protein1e-40166
NC_006177:3549467:356356735635673564184618Symbiobacterium thermophilum IAM 14863, complete genomeSpoIIIJ-associated RNA-binding protein3e-37155
NC_016935:8716704:873628387362838736903621Paenibacillus mucilaginosus 3016 chromosome, complete genomesingle-stranded nucleic acid binding R3H domain-containing protein7e-37153
NC_015690:8645500:866105486610548661674621Paenibacillus mucilaginosus KNP414 chromosome, complete genomesingle-stranded nucleic acid binding R3H domain-containing protein2e-36152
NC_017243:314000:334078334078334782705Brachyspira intermedia PWS/A chromosome, complete genomejag protein5e-34144
NC_014833:3667748:368109336810933681908816Ruminococcus albus 7 chromosome, complete genomesingle-stranded nucleic acid-binding R3H domain-containing protein8e-30130
NC_013406:7092510:711237371123737113161789Paenibacillus sp. Y412MC10 chromosome, complete genomesingle-stranded nucleic acid-binding R3H domain-containing protein4e-28124
NC_016938:1830500:184343018434301844194765Melissococcus plutonius DAT561 chromosome 1, complete genomeRNA-binding protein Jag3e-2098.2
NC_013522:736339:738824738824739519696Thermanaerovibrio acidaminovorans DSM 6589, complete genomesingle-stranded nucleic acid binding R3H domain protein5e-1994.4
NC_015436:1:690469047611708Spirochaeta coccoides DSM 17374 chromosome, complete genomesingle-stranded nucleic acid binding R3H domain-containing protein5e-1994.4
NC_013204:3613824:362942936294293629950522Eggerthella lenta DSM 2243, complete genomesingle-stranded nucleic acid binding R3H domain protein8e-1993.6
NC_015389:2101841:211332221133222113900579Coriobacterium glomerans PW2 chromosome, complete genomesingle-stranded nucleic acid binding R3H domain-containing protein1e-1893.2
NC_009616:1604276:162034616203461621017672Thermosipho melanesiensis BI429 chromosome, complete genomesingle-stranded nucleic acid binding R3H domain-containing protein5e-1891.3
NC_013165:3146000:316135731613573161923567Slackia heliotrinireducens DSM 20476, complete genomepredicted RNA-binding protein7e-1890.5
NC_014363:2035141:205038020503802050970591Olsenella uli DSM 7084 chromosome, complete genomesingle-stranded nucleic acid binding R3H domain protein2e-1788.6
NC_015387:1002955:101999210199921020588597Marinithermus hydrothermalis DSM 14884 chromosome, complete genomesingle-stranded nucleic acid binding R3H domain-containing protein1e-1686.7
NC_014210:5752651:576485457648545765342489Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111 chromosome,single-stranded nucleic acid binding R3H domain protein7e-1684
NC_016114:3655005:368074236807423681251510Streptomyces flavogriseus ATCC 33331 chromosome, complete genomesingle-stranded nucleic acid binding R3H domain-containing protein2e-1582
NC_015953:3684065:369557636955763696085510Streptomyces sp. SirexAA-E chromosome, complete genomesingle-stranded nucleic acid binding R3H domain-containing protein4e-1581.3
NC_018750:3964784:397616339761633976675513Streptomyces venezuelae ATCC 10712, complete genomeRNA-binding protein Jag4e-1581.3
NC_007333:3626510:363905136390513639590540Thermobifida fusca YX, complete genomesingle-stranded nucleic acid binding R3H5e-1580.9
NC_013595:10329633:103387611033876110339264504Streptosporangium roseum DSM 43021, complete genomespoIIIJ-associated protein1e-1479.7
NC_014151:4106624:412013541201354120647513Cellulomonas flavigena DSM 20109 chromosome, complete genomesingle-stranded nucleic acid binding R3H domain protein1e-1479.7
NC_015760:2009425:2024004202400420250471044Streptococcus salivarius CCHSS3, complete genomehypothetical protein2e-1479.3
NC_008578:2431074:244059024405902441189600Acidothermus cellulolyticus 11B, complete genomesingle-stranded nucleic acid binding R3H domain protein2e-1479
NC_006448:1604627:1617490161749016185391050Streptococcus thermophilus LMG 18311, complete genomeconserved hypothetical protein, Jag protein3e-1478.6
NC_006449:1606948:1619801161980116208501050Streptococcus thermophilus CNRZ1066, complete genomeconserved hypothetical protein, Jag protein3e-1478.6
NC_002677:3253057:326498232649823265563582Mycobacterium leprae TN, complete genomehypothetical protein3e-1478.6
NC_011896:3252925:326485032648503265431582Mycobacterium leprae Br4923, complete genomehypothetical protein3e-1478.6
NC_014221:398636:417296417296417877582Truepera radiovictrix DSM 17093 chromosome, complete genomesingle-stranded nucleic acid binding R3H domain protein9e-1477
NC_003888:4251867:427534342753434275855513Streptomyces coelicolor A3(2), complete genomehypothetical protein1e-1376.3
NC_013192:2434664:246326224632622464083822Leptotrichia buccalis DSM 1135, complete genomesingle-stranded nucleic acid binding R3H domain protein4e-1374.7
NC_015564:4727630:473582747358274736336510Amycolicicoccus subflavus DQS3-9A1 chromosome, complete genomehypothetical protein7e-1373.9
NC_014550:3839389:385665538566553857182528Arthrobacter arilaitensis Re117, complete genomeR3H domain-containing protein2e-1272.8
NC_013929:5135285:514436951443695144881513Streptomyces scabiei 87.22 chromosome, complete genomenucleic-acid-binding protein Jag4e-1271.2
NC_011886:4376261:439271143927114393277567Arthrobacter chlorophenolicus A6, complete genomesingle-stranded nucleic acid binding R3H domain protein4e-1271.6
NC_018531:4718904:473356947335694734120552Arthrobacter sp. Rue61a chromosome, complete genomejag-like protein1e-1169.7
NC_017093:8757291:877055787705578771126570Actinoplanes missouriensis 431, complete genomehypothetical protein1e-1169.3
NC_008711:4579997:459466045946604595211552Arthrobacter aurescens TC1, complete genomeputative jag-like protein2e-1169.3
NC_015145:4232283:424780242478024248368567Arthrobacter phenanthrenivorans Sphe3 chromosome, complete genomeRNA-binding protein2e-1168.9
NC_016512:2506898:251982425198242520435612Propionibacterium acnes TypeIA2 P.acn17 chromosome, completeR3H domain-containing protein4e-1168.2
NC_016516:2473500:248656124865612487172612Propionibacterium acnes TypeIA2 P.acn33 chromosome, completeR3H domain-containing protein4e-1168.2
NC_014039:2479500:249241224924122493023612Propionibacterium acnes SK137 chromosome, complete genomeR3H domain protein4e-1168.2
NC_016511:2482500:249570424957042496315612Propionibacterium acnes TypeIA2 P.acn31 chromosome, completeR3H domain-containing protein4e-1168.2
NC_006085:2544421:255734725573472557958612Propionibacterium acnes KPA171202, complete genomeJAG-like protein4e-1168.2
NC_008541:4679022:469595046959504696516567Arthrobacter sp. FB24 chromosome 1, complete sequencesingle-stranded nucleic acid binding R3H domain protein5e-1167.8
NC_017218:2313245:232474623247462325282537Bifidobacterium breve ACS-071-V-Sch8b chromosome, complete genomeR3H domain-containing protein5e-1167.8
NC_013521:4240468:425046442504644250988525Sanguibacter keddieii DSM 10542, complete genomepredicted RNA-binding protein7e-1167.4
NC_014830:4012999:402108740210874021773687Intrasporangium calvum DSM 43043 chromosome, complete genomesingle-stranded nucleic acid binding R3H domain-containing protein8e-1167
NC_018720:2138180:216415321641532164794642Bifidobacterium asteroides PRL2011 chromosome, complete genomer3H domain-containing protein1e-1066.6
NC_014656:1634397:164405016440501644583534Bifidobacterium longum subsp. longum BBMN68 chromosome, completejag1e-1066.6
NC_014638:2199799:221184722118472212377531Bifidobacterium bifidum PRL2010 chromosome, complete genomehypothetical protein2e-1066.2
NC_015067:2371428:238234523823452382878534Bifidobacterium longum subsp. longum JCM 1217, complete genomehypothetical protein3e-1065.1
NC_015052:2383865:239749323974932398026534Bifidobacterium longum subsp. infantis 157F, complete genomehypothetical protein3e-1065.1
NC_004307:1620500:162805216280521628585534Bifidobacterium longum NCC2705, complete genomenarrowly conserved hypothetical protein with possible ssDNA binding domain3e-1065.1
NC_017221:2268276:227565722756572276190534Bifidobacterium longum subsp. longum KACC 91563 chromosome,hypothetical protein3e-1065.1
NC_014169:2466442:247522824752282475761534Bifidobacterium longum subsp. longum JDM301 chromosome, completesingle-stranded nucleic acid-binding R3H domain-containing protein3e-1065.1
NC_014616:2172025:218407221840722184602531Bifidobacterium bifidum S17 chromosome, complete genomer3H domain-containing protein4e-1064.7
NC_017219:2815225:282613928261392826672534Bifidobacterium longum subsp. infantis ATCC 15697, complete genomehypothetical protein7e-1063.9
NC_011593:2819230:283013828301382830671534Bifidobacterium longum subsp. infantis ATCC 15697 chromosome,single-stranded nucleic acid binding R3H domain-containing protein7e-1063.9
NC_010816:1660066:166971816697181670251534Bifidobacterium longum DJO10A, complete genomeHypothetical RNA-binding protein7e-1063.9
NC_013161:4209554:422552742255274226015489Cyanothece sp. PCC 8802, complete genomesingle-stranded nucleic acid binding R3H domain protein9e-0960.5