Pre_GI: BLASTP Hits

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Query: NC_008258:269806:280503 Shigella flexneri 5 str. 8401, complete genome

Start: 280503, End: 281159, Length: 657

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Shigella spp. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012947:3015985:302686930268693027417549Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completehypothetical protein1e-1789.7
NC_004431:1401681:140521014052101405668459Escherichia coli CFT073, complete genomehypothetical protein5e-24110
NC_009800:289000:294476294476295159684Escherichia coli HS, complete genomehypothetical protein2e-55215
AP010958:5361207:536932553693255370095771Escherichia coli O103:H2 str. 12009 DNA, complete genomehypothetical protein9e-1993.6
AP010958:2911741:291625929162592916960702Escherichia coli O103:H2 str. 12009 DNA, complete genomehypothetical protein1e-1582.8
NC_013353:2911741:291625929162592916960702Escherichia coli O103:H2 str. 12009, complete genomehypothetical protein1e-1582.8
NC_013353:5361207:536932553693255370095771Escherichia coli O103:H2 str. 12009, complete genomehypothetical protein9e-1993.6
NC_013364:1183000:118766411876641188218555Escherichia coli O111:H- str. 11128, complete genomehypothetical protein1e-25116
NC_013364:2645438:265686626568662657420555Escherichia coli O111:H- str. 11128, complete genomehypothetical protein1e-25116
NC_011601:1039500:104556610455661046234669Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomehypothetical protein2e-26119
NC_011601:2614691:262714526271452627783639Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomehypothetical protein3e-1788.6
NC_011601:717072:724147724147724785639Escherichia coli O127:H6 str. E2348/69 chromosome, complete genomehypothetical protein3e-1788.6
NC_002655:1332961:133493113349311335704774Escherichia coli O157:H7 EDL933, complete genomeunknown protein encoded by bacteriophage BP-933W3e-1995.1
NC_011353:3276734:328974332897433290690948Escherichia coli O157:H7 str. EC4115 chromosome, complete genomehypothetical protein8e-24110
NC_013008:3231414:324461432446143245561948Escherichia coli O157:H7 str. TW14359 chromosome, complete genomehypothetical protein8e-24110
NC_013361:1558423:156413515641351564542408Escherichia coli O26:H11 str. 11368 chromosome, complete genomehypothetical protein8e-1580.5
NC_013361:3287671:330152033015203302188669Escherichia coli O26:H11 str. 11368 chromosome, complete genomehypothetical protein1e-24112
NC_013941:3300000:330852533085253309343819Escherichia coli O55:H7 str. CB9615 chromosome, complete genomeenterohemolysin 21e-1892.8
NC_007946:2625461:263614426361442636716573Escherichia coli UTI89, complete genomehypothetical protein2e-1892.4
NC_011083:374000:380217380217380702486Salmonella enterica subsp. enterica serovar Heidelberg str. SL476,protein ea221e-1789.7
NC_016860:364981:371050371050371841792Salmonella enterica subsp. enterica serovar Typhimurium strhypothetical protein2e-24112
NC_017328:303987:313288313288313737450Shigella flexneri 2002017 chromosome, complete genomehypothetical protein7e-1684