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Query: NC_008150:4373722:4373722 Yersinia pestis Antiqua, complete genome

Start: 4373722, End: 4374258, Length: 537

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from the Republic of Congo. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017265:4065625:406562540656254066161537Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein2e-102370
NC_005810:4306716:430671643067164307252537Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein2e-102370
NC_003143:398748:417807417807418343537Yersinia pestis CO92, complete genomehypothetical protein2e-102370
NC_004088:4202247:420224742022474202783537Yersinia pestis KIM, complete genomehypothetical protein2e-102370
NC_008149:318860:337015337015337551537Yersinia pestis Nepal516, complete genomehypothetical protein2e-102370
NC_009381:3680638:368063836806383681174537Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein2e-102370
NC_014029:452248:471307471307471843537Yersinia pestis Z176003 chromosome, complete genomehypothetical protein2e-102370
NC_017154:394401:413459413459413995537Yersinia pestis D106004 chromosome, complete genomehypothetical protein2e-102370
NC_017160:396600:415659415659416195537Yersinia pestis D182038 chromosome, complete genomehypothetical protein2e-102370
NC_017168:687471:687471687471688007537Yersinia pestis A1122 chromosome, complete genomehypothetical protein2e-102370
NC_004129:4434259:445597044559704456512543Pseudomonas fluorescens Pf-5, complete genomehypothetical protein4e-43174
NC_004431:1211000:122089512208951221437543Escherichia coli CFT073, complete genomehypothetical protein1e-30132