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Query: NC_008149:1221637:1242339 Yersinia pestis Nepal516, complete genome

Start: 1242339, End: 1242830, Length: 492

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Isolated from a soil sample from Nepal. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015663:3586836:359169935916993592181483Enterobacter aerogenes KCTC 2190 chromosome, complete genomehypothetical protein5e-54209
NC_014121:3188928:318892831889283189401474Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, completecold-shock DNA-binding domain protein8e-54209
NC_014306:3006028:302735430273543027836483Erwinia billingiae Eb661, complete genomePutative cold-shock protein4e-54210
NC_012214:1212616:123125412312541231736483Erwinia pyrifoliae Ep1/96, complete genomecold-shock protein2e-57221
NC_012731:3193880:321734032173403217822483Klebsiella pneumoniae NTUH-K2044 chromosome, complete genomecold shock protein E1e-52205
NC_016845:3238507:326614032661403266622483Klebsiella pneumoniae subsp. pneumoniae HS11286 chromosome,cold shock protein E1e-52205
NC_009648:2465613:249493324949332495415483Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genomecold shock protein E1e-52205
NC_013421:3117639:312844431284443128926483Pectobacterium wasabiae WPP163, complete genomecold-shock DNA-binding domain protein3e-54210
NC_020064:1150982:116396511639651164441477Serratia marcescens FGI94, complete genomecold shock protein5e-60229
NC_009832:1280938:130060113006011301092492Serratia proteamaculans 568, complete genomecold-shock DNA-binding domain protein6e-67252
NC_008800:3279468:328325432832543283733480Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,hypothetical protein5e-86316
NC_015224:1440283:145424314542431454722480Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,hypothetical protein9e-86315
NC_008150:2785830:279411127941112794602492Yersinia pestis Antiqua, complete genomehypothetical protein8e-91332
NC_003143:2895617:291629729162972916668372Yersinia pestis CO92, complete genomehypothetical protein4e-64243
NC_004088:1291754:131242813124281312919492Yersinia pestis KIM, complete genomecold-shock protein8e-91332