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Query: NC_007797:441782:458719 Anaplasma phagocytophilum HZ, complete genome

Start: 458719, End: 460512, Length: 1794

Host Lineage: Anaplasma phagocytophilum; Anaplasma; Anaplasmataceae; Rickettsiales; Proteobacteria; Bacteria

General Information: Isolated from a patient in New York, USA, in 1995. This organism is a tick-borne (Ixodesspp.) obligate intracellular pathogen that infects humans and causes human granulocytic anaplasmosis as well as infecting several other types of animals. This organism produces a number of pathogenic factors that aid virulence. These include specific adhesins for neutrophils, virulence factors that inhibit both phagosome-lysozome fusion and production of reactive oxygen species that would normally kill the bacterium. The bacterium also inhibits programmed cell death of the neutrophil (apoptosis) and induces expression of interleukin-8, which causes neutrophil chemotaxis, thereby increasing the spread of the bacterium throughout the host organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_007799:555900:5602795602795620301752Ehrlichia chaffeensis str. Arkansas, complete genomeputative lipoprotein2e-1171.2
NC_006832:776286:7913877913877933061920Ehrlichia ruminantium str. Welgevonden, complete genomehypothetical protein5e-1066.6
NC_005295:796437:8115388115388134571920Ehrlichia ruminantium str. Welgevonden, complete genomehypothetical protein5e-1066.6
NC_006831:772737:7875857875857893031719Ehrlichia ruminantium str. Gardel, complete genomehypothetical protein8e-1065.9