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Query: NC_007613:4119771:4134474 Shigella boydii Sb227, complete genome

Start: 4134474, End: 4134824, Length: 351

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is an isolate from an epidemic that took place in China in the 1950s. Causes dysentery. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. Shigella boydii is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010658:4257310:427311142731114273392282Shigella boydii CDC 3083-94, complete genomehypothetical protein9e-48188
NC_006905:4405301:443615444361544436525372Salmonella enterica subsp. enterica serovar Choleraesuis strputative inner membrane protein6e-44176
NC_010067:3310336:331828933182893318570282Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein1e-41167
NC_020181:3585898:360778036077803608001222Enterobacter aerogenes EA1509E, complete genomeYjcB protein1e-24112
NC_020064:2299950:231791223179122318193282Serratia marcescens FGI94, complete genomehypothetical protein9e-1785.5