Pre_GI: BLASTP Hits

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Query: NC_005945:1103729:1119281 Bacillus anthracis str. Sterne, complete genome

Start: 1119281, End: 1119568, Length: 288

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain carries the anthrax toxin plasmid pXO1 but not the capsule plasmid pXO2 and is therefore avirulent but toxigenic. It is the counterpart to the Pasteur strain that carries pXO2 but not pXO1. This strain is often used for vaccine development. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:1103737:111928911192891119576288Bacillus anthracis str. A0248, complete genomehypothetical protein9e-41165
NC_003909:1244000:125859012585901258877288Bacillus cereus ATCC 10987, complete genomehypothetical protein1e-37154
NC_004722:1108649:112422911242291124516288Bacillus cereus ATCC 14579, complete genomehypothetical protein2e-34144
NC_011725:1150779:116628611662861166573288Bacillus cereus B4264 chromosome, complete genomehypothetical protein3e-37153
NC_014335:1094000:110904011090401109327288Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein8e-40162
NC_011772:1094534:111018811101881110475288Bacillus cereus G9842, complete genomehypothetical protein1e-36151
NC_011969:1181302:119556811955681195855288Bacillus cereus Q1 chromosome, complete genomehypothetical protein7e-38155
NC_014171:1118000:113208311320831132370288Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein4e-36149
NC_017208:1147230:116277811627781163065288Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein1e-37154
NC_010184:1114000:112549811254981125776279Bacillus weihenstephanensis KBAB4, complete genomehypothetical protein3e-34143