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Query: NC_005810:3272765:3279687 Yersinia pestis biovar Microtus str. 91001, complete genome

Start: 3279687, End: 3280133, Length: 447

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013757:1888850:191455819145581914992435Geodermatophilus obscurus DSM 43160, complete genomePolyketide cyclase/dehydrase2e-0651.2
NC_010159:1071937:107900410790041079441438Yersinia pestis Angola, complete genomehypothetical protein5e-82302
NC_008150:3495851:350613935061393506585447Yersinia pestis Antiqua, complete genomehypothetical protein8e-84308
NC_017265:3790750:379860037986003799046447Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein8e-84308
NC_003143:675622:686855686855687301447Yersinia pestis CO92, complete genomehypothetical protein8e-84308
NC_017154:671816:682525682525682962438Yersinia pestis D106004 chromosome, complete genomehypothetical protein5e-82302
NC_017160:676249:684710684710685147438Yersinia pestis D182038 chromosome, complete genomehypothetical protein5e-82302
NC_004088:3923804:393323839332383933684447Yersinia pestis KIM, complete genomehypothetical protein8e-84308
NC_008149:587689:598385598385598831447Yersinia pestis Nepal516, complete genomehypothetical protein8e-84308
NC_009381:460358:468822468822469268447Yersinia pestis Pestoides F chromosome, complete genomehypothetical protein8e-84308
NC_014029:729675:740373740373740810438Yersinia pestis Z176003 chromosome, complete genomehypothetical protein5e-82302
NC_009708:633054:639985639985640422438Yersinia pseudotuberculosis IP 31758 chromosome, complete genomehypothetical protein5e-82302
NC_006155:4062000:407183940718394072285447Yersinia pseudotuberculosis IP 32953, complete genomehypothetical protein8e-84308
NC_010634:4001154:401204540120454012482438Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein5e-82302
NC_010465:660207:667138667138667575438Yersinia pseudotuberculosis YPIII, complete genomehypothetical protein5e-82302
NC_015709:1769806:178295217829521783401450Zymomonas mobilis subsp. pomaceae ATCC 29192 chromosome, completepolyketide cyclase/dehydrase2e-1375.1