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Query: NC_004851:191709:485 Shigella flexneri 2a str. 301 plasmid pCP301, complete sequence

Start: 485, End: 949, Length: 465

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009927:253250:2726972726972748622166Acaryochloris marina MBIC11017 plasmid pREB2, complete sequencetransposase, putative3e-1580.9
NC_010815:40357:5206352063549872925Geobacter lovleyi SZ plasmid pGLOV01, complete sequencetransposase Tn3 family protein6e-22102
NC_008607:11663:3438034380372322853Pelobacter propionicus DSM 2379 plasmid pPRO1, complete sequencetransposase Tn3 family protein9e-0959.3
NC_009142:5698100:570629657062965706526231Saccharopolyspora erythraea NRRL 2338, complete genometransposase Tn39e-1165.9
NC_008258:1934479:1953851195385119576163766Shigella flexneri 5 str. 8401, complete genome3e-0651.2
NC_011662:2374955:2386933238693323898992967Thauera sp. MZ1T, complete genometransposase Tn3 family protein2e-0755.1