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Query: NC_004851:191709:208897 Shigella flexneri 2a str. 301 plasmid pCP301, complete sequence

Start: 208897, End: 209157, Length: 261

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010660:175200:192565192565192825261Shigella boydii CDC 3083-94 plasmid pBS512_211, complete sequencereplication regulatory protein RepA24e-44176
NC_007607:87000:106454106454106714261Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequenceRepB4e-44176
NC_007608:97092:111757111757112017261Shigella boydii Sb227 plasmid pSB4_227, complete sequenceRepB4e-44176
NC_017319:192482:208849208849209040192Shigella flexneri 2002017 plasmid pSFxv_1, complete sequenceRepB protein6e-30129
NC_011749:34056:521805218052440261Escherichia coli UMN026 plasmid p1ESCUM, complete sequencereplication protein7e-1475.9
NC_016846:24500:393813938139650270Klebsiella pneumoniae subsp. pneumoniae HS11286 plasmid pKPHS2,replication regulatory protein RepA22e-1374.3