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Query: NC_004851:191709:205985 Shigella flexneri 2a str. 301 plasmid pCP301, complete sequence

Start: 205985, End: 206287, Length: 303

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017319:192482:205868205868206170303Shigella flexneri 2002017 plasmid pSFxv_1, complete sequencehypothetical protein4e-53206
NC_010660:175200:190143190143190643501Shigella boydii CDC 3083-94 plasmid pBS512_211, complete sequence2e-51201
NC_011749:34056:535635356354099537Escherichia coli UMN026 plasmid p1ESCUM, complete sequencenuclease2e-45181
NC_007608:97092:110172110172110633462Shigella boydii Sb227 plasmid pSB4_227, complete sequencehypothetical protein3e-39160
NC_007607:87000:103259103259103561303Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequencehypothetical protein4e-36149
NC_016616:760145:768659768659769195537Dechlorosoma suillum PS chromosome, complete genomemicrococcal nuclease-like nuclease5e-1063.2
NC_009715:1829978:186455318645531864999447Campylobacter curvus 525.92 chromosome, complete genomeATP-dependent hsl protease ATP-binding subunit HslU5e-0959.7
NC_013132:782846:798974798974799489516Chitinophaga pinensis DSM 2588, complete genomenuclease (SNase domain protein)2e-0857.8
NC_016616:2112211:211854521185452119039495Dechlorosoma suillum PS chromosome, complete genomemicrococcal nuclease-like nuclease2e-0754.7
NC_014972:210500:217951217951218613663Desulfobulbus propionicus DSM 2032 chromosome, complete genomenuclease2e-0754.3
NC_011667:1:391239124400489Thauera sp. MZ1T plasmid pTha01, complete sequencenuclease (SNase domain protein)3e-0753.9
NC_008786:4070753:407453540745354074996462Verminephrobacter eiseniae EF01-2, complete genomenuclease (SNase domain protein)3e-0753.9
NC_012796:4693500:472231247223124722971660Desulfovibrio magneticus RS-1, complete genomeputative nuclease6e-0752.8
NC_009481:1927995:193761319376131938212600Synechococcus sp. WH 7803 chromosome, complete genomenuclease-like protein2e-0651.2