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Query: NC_004851:191709:198515 Shigella flexneri 2a str. 301 plasmid pCP301, complete sequence

Start: 198515, End: 198742, Length: 228

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1984 from a patient in Beijing, China. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017319:192482:198443198443198670228Shigella flexneri 2002017 plasmid pSFxv_1, complete sequenceplasmid maintenance protein6e-38155
NC_007608:97092:102618102618102845228Shigella boydii Sb227 plasmid pSB4_227, complete sequenceplasmid maintenance protein2e-37154
NC_007607:87000:957819578196008228Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequenceplasmid maintenance protein1e-36151
NC_003198:3042000:305178630517863052013228Salmonella enterica subsp. enterica serovar Typhi str. CT18,hypothetical protein (assiciated with virulence)6e-27119
NC_004631:3030580:303769330376933037920228Salmonella enterica subsp. enterica serovar Typhi Ty2, completehypothetical protein6e-27119
NC_012912:4167429:417252841725284172758231Dickeya zeae Ech1591, complete genomeputative plasmid protein1e-23108
NC_015740:2407500:242348224234822423712231Pseudomonas stutzeri ATCC 17588 = LMG 11199 chromosome, completeMvpT1e-2098.2
NC_015581:1043394:105424010542401054476237Thioalkalimicrobium cyclicum ALM1 chromosome, complete genomevirulence-associated protein1e-1891.7
NC_008702:369965:376345376345376629285Azoarcus sp. BH72, complete genomeconserved hypothetical protein7e-1682.4
NC_010995:4297361:431437943143794314612234Cellvibrio japonicus Ueda107, complete genomepossible virulence-associated protein5e-1373.2
NC_010278:1918000:192918819291881929418231Actinobacillus pleuropneumoniae serovar 3 str. JL03 chromosome,hypothetical protein2e-1270.9
NC_010939:1986263:199275919927591992989231Actinobacillus pleuropneumoniae serovar 7 str. AP76, completehypothetical protein5e-1269.7
NC_009053:1942973:196787719678771968107231Actinobacillus pleuropneumoniae L20, complete genomehypothetical protein5e-1269.7
NC_008463:2467219:247859024785902478874285Pseudomonas aeruginosa UCBPP-PA14, complete genomehypothetical protein9e-1268.9