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Query: NC_004741:2593012:2611291 Shigella flexneri 2a str. 2457T, complete genome

Start: 2611291, End: 2612118, Length: 828

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008344:2374761:237967723796772380504828Nitrosomonas eutropha C91, complete genomeputative DNA helicase7e-155546
NC_008344:669498:684756684756685583828Nitrosomonas eutropha C91, complete genomeputative DNA helicase7e-155546
NC_013456:3011518:302807030280703028921852Vibrio sp. Ex25 chromosome 1, complete genomeputative DNA helicase1e-114412
NC_003384:157158:164126164126164842717Salmonella enterica subsp. enterica serovar Typhi str. CT18 plasmid4e-110397
NC_013365:92973:111529111529112236708Escherichia coli O111:H- str. 11128 plasmid pO111_1, complete2e-108391
NC_016602:2854107:287272928727292873250522Vibrio furnissii NCTC 11218 chromosome 1, complete sequencereplication protein A3e-75281
NC_013722:1816561:186251518625151863393879Xanthomonas albilineans, complete genomehypothetical protein1e-65249
NC_007508:2783443:279982227998222800697876Xanthomonas campestris pv. vesicatoria str. 85-10, complete genomeReplication protein A1e-62239
NC_008463:1293079:130405213040521304930879Pseudomonas aeruginosa UCBPP-PA14, complete genomereplicative helicase, RepA3e-62238
NC_011283:1307173:131078713107871311665879Klebsiella pneumoniae 342 chromosome, complete genomeregulatory protein RepA6e-62237
NC_012796:1600600:162501716250171625904888Desulfovibrio magneticus RS-1, complete genomehypothetical protein1e-41169
NC_015186:1126830:113779711377971138609813Acidiphilium multivorum AIU301, complete genomehypothetical protein3e-38159
NC_016745:2028424:204018220401822040562381Oceanimonas sp. GK1 chromosome, complete genomereplication protein A1e-34147
NC_015422:3581848:3592064359206435935361473Alicycliphilus denitrificans K601 chromosome, complete genomePrimase 12e-1996.3
NC_011768:5900500:5908211590821159096051395Desulfatibacillum alkenivorans AK-01, complete genomeRecA-family ATPase-like protein4e-1995.1
NC_015186:1126830:113966611396661140073408Acidiphilium multivorum AIU301, complete genomehypothetical protein1e-1170.5
NC_014307:233045:2474232474232495462124Ralstonia solanacearum CFBP2957 chromosome, complete genometoprim domain protein3e-0755.8