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Query: NC_004741:2593012:2608282 Shigella flexneri 2a str. 2457T, complete genome

Start: 2608282, End: 2609061, Length: 780

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008344:2374761:238273423827342383513780Nitrosomonas eutropha C91, complete genomeputative mating pair formation protein8e-97353
NC_008344:669498:681747681747682526780Nitrosomonas eutropha C91, complete genomeputative mating pair formation protein8e-97353
NC_013456:3011518:302554130255413026311771Vibrio sp. Ex25 chromosome 1, complete genomeconjugative transfer protein TrbJ9e-64243
NC_016745:2028424:204472320447232045472750Oceanimonas sp. GK1 chromosome, complete genomeconjugal transfer protein TrbJ3e-56218
NC_016602:2854107:286975128697512870539789Vibrio furnissii NCTC 11218 chromosome 1, complete sequencemating pair formation protein1e-52206
NC_008463:1293079:131329113132911314076786Pseudomonas aeruginosa UCBPP-PA14, complete genomemating pair formation protein TrbJ1e-49196
NC_008800:1300500:131858813185881319367780Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,conjugal transfer protein TrbJ1e-39163
NC_009800:2651730:266052426605242661318795Escherichia coli HS, complete genomeP-type conjugative transfer protein TrbJ2e-37156
NC_020063:3690308:372791137279113728705795Enterobacteriaceae bacterium strain FGI 57, complete genomeP-type conjugative transfer protein TrbJ1e-35150
NC_013722:1816561:185838418583841859157774Xanthomonas albilineans, complete genomeputative conjugal transfer protein3e-34145
NC_006350:3865584:387917138791713879950780Burkholderia pseudomallei K96243 chromosome 1, complete sequenceputative plasmid conjugal transfer protein1e-32139
NC_011000:183928:194371194371195144774Burkholderia cenocepacia J2315 chromosome 1, complete sequenceconjugal transfer protein TrbJ4e-32138