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Query: NC_004741:2593012:2607237 Shigella flexneri 2a str. 2457T, complete genome

Start: 2607237, End: 2608043, Length: 807

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This is a highly virulent strain that has been widely used for genetic and clinical research. Causes enteric disease. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008344:2374761:2383773238377323852001428Nitrosomonas eutropha C91, complete genomeTrbL/VirB6 plasmid conjugal transfer protein4e-105380
NC_008344:669498:6800606800606814871428Nitrosomonas eutropha C91, complete genomeTrbL/VirB6 plasmid conjugal transfer protein4e-105380
NC_013456:3011518:3023677302367730252811605Vibrio sp. Ex25 chromosome 1, complete genomeconjugative transfer protein TrbL2e-71269
NC_016602:2854107:2867942286794228695641623Vibrio furnissii NCTC 11218 chromosome 1, complete sequenceTrbL/VirB6 plasmid conjugal transfer protein4e-36151
NC_008800:1300500:1316984131698413183841401Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,putative conjugal transfer protein4e-36151
NC_016745:2028424:2045659204565920472781620Oceanimonas sp. GK1 chromosome, complete genomeTrbL/VirB6 plasmid conjugal transfer protein3e-35148
NC_006513:38818:4999349993515971605Azoarcus sp. EbN1, complete genomeplasmid like TrbL protein, component of conjugation system7e-33140
NC_009800:2651730:2658945265894526603361392Escherichia coli HS, complete genomeP-type conjugative transfer protein TrbL1e-26120
NC_020063:3690308:3726329372632937277231395Enterobacteriaceae bacterium strain FGI 57, complete genomeP-type conjugative transfer protein TrbL7e-25114
NC_008463:1293079:1314366131436613159881623Pseudomonas aeruginosa UCBPP-PA14, complete genomeputative mating pair formation protein TrbL1e-24113
NC_008782:2683989:2701523270152327031211599Acidovorax sp. JS42, complete genomeTrbL/VirB6 plasmid conjugal transfer protein4e-23108
NC_013722:1816561:1856743185674318581701428Xanthomonas albilineans, complete genomeputative conjugal transfer protein2e-2099.4
NC_011000:183928:1953651953651967921428Burkholderia cenocepacia J2315 chromosome 1, complete sequenceputative plasmid conjugal transfer protein6e-1994.7
NC_006350:3865584:3877520387752038789501431Burkholderia pseudomallei K96243 chromosome 1, complete sequenceputative plasmid conjugal transfer protein4e-1892
NC_007005:5500196:550704355070435508014972Pseudomonas syringae pv. syringae B728a, complete genomeconjugal transfer protein5e-0755.1
NC_006371:1743982:1752944175294417542571314Photobacterium profundum SS9 chromosome 2, complete sequencehypothetical TrbL protein5e-0755.1
NC_011283:1307173:1313264131326413148681605Klebsiella pneumoniae 342 chromosome, complete genomeP-type conjugative transfer protein TrbL1e-0653.9
NC_015733:1179977:1191396119139611929821587Pseudomonas putida S16 chromosome, complete genomeP-type conjugative transfer protein TrbL4e-0652.4