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Query: NC_004557:806878:817556 Clostridium tetani E88, complete genome

Start: 817556, End: 823198, Length: 5643

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_004557:806878:8068788068788085841707Clostridium tetani E88, complete genomeputative surface/cell-adhesion protein1e-78296
NC_004557:806878:8164028164028174691068Clostridium tetani E88, complete genomeputative surface/cell-adhesion protein2e-60236
NC_004557:806878:8086628086628104731812Clostridium tetani E88, complete genomeputative surface/cell-adhesion protein, big2 domain7e-59230
NC_004557:806878:8107428107428118661125Clostridium tetani E88, complete genomeputative surface/cell-adhesion protein4e-58228
NC_004557:806878:8119028119028129841083Clostridium tetani E88, complete genomeputative surface/cell-adhesion protein1e-55220
NC_014328:2426921:2436213243621324391222910Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative cell wall-binding protein9e-52207
NC_004557:806878:8130058130058150082004Clostridium tetani E88, complete genomeN-acetylmuramoyl-L-alanine amidase5e-51204
NC_014328:2426921:2439223243922324422493027Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative surface/cell-adhesion protein3e-49198
NC_014328:2426921:2430181243018124320701890Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative cell wall-binding protein1e-45186
NC_018515:595500:6153216153216173332013Desulfosporosinus meridiei DSM 13257 chromosome, complete genomecell wall-binding protein2e-38162
NC_016935:2567039:2582935258293525875124578Paenibacillus mucilaginosus 3016 chromosome, complete genomehypothetical protein9e-36154
NC_018515:595500:6087396087396120533315Desulfosporosinus meridiei DSM 13257 chromosome, complete genomeWD40-like repeat protein6e-35151
NC_016894:3527364:3527364352736435311793816Acetobacterium woodii DSM 1030 chromosome, complete genomeputative cell surface protein7e-27124
NC_014833:3362500:3374340337434033755121173Ruminococcus albus 7 chromosome, complete genomehypothetical protein2e-1586.3
NC_018515:595500:6120286120286152403213Desulfosporosinus meridiei DSM 13257 chromosome, complete genomecell wall-binding protein5e-1275.1
NC_016023:1769925:1807545180754518089721428Bacillus coagulans 36D1 chromosome, complete genomeLPXTG-motif cell wall anchor domain-containing protein4e-1172.4
NC_016791:2888319:2908662290866229127954134Clostridium sp. BNL1100 chromosome, complete genomehypothetical protein1e-0967
NC_015634:2694706:269470626947062695461756Bacillus coagulans 2-6 chromosome, complete genomehypothetical protein4e-0655.5
NC_016023:1769925:180678318067831807538756Bacillus coagulans 36D1 chromosome, complete genomehypothetical protein5e-0655.1