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Query: NC_004557:806878:811902 Clostridium tetani E88, complete genome

Start: 811902, End: 812984, Length: 1083

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_004557:806878:8107428107428118661125Clostridium tetani E88, complete genomeputative surface/cell-adhesion protein4e-117421
NC_004557:806878:8086628086628104731812Clostridium tetani E88, complete genomeputative surface/cell-adhesion protein, big2 domain2e-66252
NC_004557:806878:8175568175568231985643Clostridium tetani E88, complete genomeputative surface/cell-adhesion protein3e-56219
NC_018515:595500:6120286120286152403213Desulfosporosinus meridiei DSM 13257 chromosome, complete genomecell wall-binding protein9e-1168.2
NC_014328:2426921:2439223243922324422493027Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative surface/cell-adhesion protein1e-0861.2