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Query: NC_004557:455895:457791 Clostridium tetani E88, complete genome

Start: 457791, End: 458288, Length: 498

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_021182:4829000:485483348548334855333501Clostridium pasteurianum BC1, complete genomepreprotein translocase subunit SecA (ATPase, RNA helicase)4e-44177
NC_009012:75000:925589255893061504Clostridium thermocellum ATCC 27405, complete genomeSEC-C motif containing protein2e-34144
NC_014721:508000:5186055186055211512547Caldicellulosiruptor kristjanssonii 177R1B chromosome, completepreprotein translocase, seca subunit3e-0650.8
NC_015949:1957185:1967416196741619699622547Caldicellulosiruptor lactoaceticus 6A chromosome, complete genomeProtein translocase subunit secA3e-0650.8
NC_009437:1481064:1491520149152014940662547Caldicellulosiruptor saccharolyticus DSM 8903, complete genomepreprotein translocase, SecA subunit4e-0650.8