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Query: NC_004557:32094:37641 Clostridium tetani E88, complete genome

Start: 37641, End: 38144, Length: 504

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008593:2527064:253269025326902533199510Clostridium novyi NT, complete genomehypothetical protein1e-34145
NC_014393:1:151741517415683510Clostridium cellulovorans 743B chromosome, complete genomemetal-dependent phosphohydrolase HD sub domain8e-33139
NC_015425:2752482:275809827580982758562465Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein3e-29127
NC_012563:1:146241462415076453Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein7e-22103
NC_010516:1:144711447114923453Clostridium botulinum B1 str. Okra, complete genomehypothetical protein6e-22103
NC_017297:1:144181441814870453Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein6e-22103
NC_009495:1:144271442714879453Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein4e-22103
NC_009697:1:144421444214894453Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein4e-22103
NC_009698:1:144421444214894453Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein4e-22103
NC_008261:1:154221542215925504Clostridium perfringens ATCC 13124, complete genomehypothetical protein4e-22103
NC_014328:1:145991459915102504Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein1e-21102
NC_009706:1:148251482515238414Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein4e-2097.4
NC_011837:1:148251482515238414Clostridium kluyveri NBRC 12016, complete genomehypothetical protein4e-2097.4
NC_009699:1:143821438214804423Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein4e-2097.1
NC_010520:1:144511445114873423Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein1e-1995.9
NC_010674:1:146791467915182504Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein4e-1994
NC_003030:1:147351473515211477Clostridium acetobutylicum ATCC 824, complete genomePredicted HD superfamily hydrolase9e-1992.8
NC_015687:1:147351473515211477Clostridium acetobutylicum DSM 1731 chromosome, complete genomeHD superfamily hydrolase9e-1992.8
NC_010723:1:146331463315136504Clostridium botulinum E3 str. Alaska E43, complete genomeputative HD domain6e-1890.1
NC_012658:1:145621456215014453Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein7e-1786.3
NC_003366:1:156331563315926294Clostridium perfringens str. 13, complete genomehypothetical protein7e-1476.6
NC_020291:1:146841468415193510Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeputative domain HDIG-containing protein5e-1270.1