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Query: NC_004557:2607073:2608309 Clostridium tetani E88, complete genome

Start: 2608309, End: 2609397, Length: 1089

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:3689422:3689422368942236905011080Clostridium difficile CD196 chromosome, complete genomeATP/GTP-binding protein7e-55214
NC_011830:2940500:2957703295770329588211119Desulfitobacterium hafniense DCB-2, complete genomehypothetical protein7e-55214
NC_015275:3243689:3247179324717932482791101Clostridium lentocellum DSM 5427 chromosome, complete genomehypothetical protein4e-53208
NC_015565:530000:5367255367255378461122Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completehypothetical protein1e-49197
NC_015589:814530:8414988414988426251128Desulfotomaculum ruminis DSM 2154 chromosome, complete genomehypothetical protein5e-45181
NC_016023:1923170:1924357192435719254361080Bacillus coagulans 36D1 chromosome, complete genomehypothetical protein7e-28125
NC_012914:3315947:3319323331932333204141092Paenibacillus sp. JDR-2, complete genomehypothetical protein3e-26119
NC_016627:2524307:254204325420432542351309Clostridium clariflavum DSM 19732 chromosome, complete genomeArgK protein3e-24112
NC_013406:7024149:7049298704929870504071110Paenibacillus sp. Y412MC10 chromosome, complete genomehypothetical protein4e-23108
NC_009454:713892:729994729994730326333Pelotomaculum thermopropionicum SI, complete genomehypothetical protein2e-1997.4