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Query: NC_004557:2552418:2555325 Clostridium tetani E88, complete genome

Start: 2555325, End: 2556050, Length: 726

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012563:3729817:375302037530203753754735Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein8e-43173
NC_009699:3581376:360458036045803605314735Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein1e-42173
NC_009697:3463736:348693434869343487668735Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein3e-42171
NC_009495:3502000:351094635109463511680735Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein3e-42171
NC_015555:693461:707062707062707739678Thermoanaerobacterium xylanolyticum LX-11 chromosome, completeSNARE associated Golgi protein-like protein4e-29128
NC_014410:2149886:215677721567772157466690Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,SNARE associated Golgi protein8e-29127
NC_019970:2190695:220060122006012201278678Thermoanaerobacterium thermosaccharolyticum M0795, complete genomehypothetical protein2e-28125
NC_017297:3594000:360319636031963603666471Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein1e-27123
NC_013967:827150:844055844055844780726Haloferax volcanii DS2 chromosome, complete genomeDedA family5e-1684.7
NC_012029:1604291:161339816133981614102705Halorubrum lacusprofundi ATCC 49239 chromosome 1, complete genomeSNARE associated Golgi protein2e-1479.3
NC_013204:3491441:349643934964393497257819Eggerthella lenta DSM 2243, complete genomeSNARE associated Golgi protein6e-1271.2
NC_010520:2807429:282162728216272822346720Clostridium botulinum A3 str. Loch Maree, complete genomeDedA family protein1e-1170.1
NC_017297:2796000:280701528070152807734720Clostridium botulinum F str. 230613 chromosome, complete genomeDedA family protein3e-1168.9
NC_010516:2777205:279108927910892791808720Clostridium botulinum B1 str. Okra, complete genomeDedA family protein1e-1067
NC_009464:180335:190897190897191577681Uncultured methanogenic archaeon RC-I, complete genomehypothetical protein3e-1065.9
NC_010516:2777205:279038627903862791123738Clostridium botulinum B1 str. Okra, complete genomeDedA family protein3e-1065.5
NC_010520:2807429:282092428209242821661738Clostridium botulinum A3 str. Loch Maree, complete genomeDedA family protein4e-1065.1
NC_017297:2796000:280631228063122807049738Clostridium botulinum F str. 230613 chromosome, complete genomeDedA family protein2e-0963.2
NC_018665:2563375:256901525690152569668654Exiguobacterium antarcticum B7 chromosome, complete genomeSNARE associated Golgi family protein5e-0754.7
NC_008212:1759535:176638017663801767144765Haloquadratum walsbyi DSM 16790, complete genomehypothetical protein2e-0653.1
NC_010556:2773396:277921927792192779872654Exiguobacterium sibiricum 255-15, complete genomeSNARE associated Golgi protein4e-0652