Pre_GI: BLASTP Hits

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Query: NC_004088:266543:278315 Yersinia pestis KIM, complete genome

Start: 278315, End: 278800, Length: 486

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:1631052:164867316486731649158486Yersinia pestis A1122 chromosome, complete genomehypothetical protein3e-91333
NC_005810:4469156:448112244811224481607486Yersinia pestis biovar Microtus str. 91001, complete genomehypothetical protein3e-91333
NC_020209:4643901:465303346530334653506474Pseudomonas poae RE*1-1-14, complete genomehypothetical protein6e-31133
NC_011898:1802971:181956418195641820028465Clostridium cellulolyticum H10, complete genomehypothetical protein1e-0962
NC_017265:4265659:426924842692484269733486Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,hypothetical protein3e-91333
NC_014029:3958811:397643239764323976917486Yersinia pestis Z176003 chromosome, complete genomehypothetical protein3e-91333
NC_014121:1589389:160218016021801602662483Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, completehypothetical protein6e-49192
NC_003228:2010643:203942220394222040360939Bacteroides fragilis NCTC 9343, complete genomehypothetical protein3e-1580.9
NC_017154:3898925:391654639165463917031486Yersinia pestis D106004 chromosome, complete genomehypothetical protein3e-91333
NC_003143:4006884:402450540245054024990486Yersinia pestis CO92, complete genomehypothetical protein3e-91333
NC_003228:2010643:203538920353892036378990Bacteroides fragilis NCTC 9343, complete genomehypothetical protein1e-1582
NC_017160:4073611:408538440853844085869486Yersinia pestis D182038 chromosome, complete genomehypothetical protein3e-91333
NC_008149:4053363:406513640651364065621486Yersinia pestis Nepal516, complete genomehypothetical protein3e-91333
NC_010501:4311873:432250743225074322980474Pseudomonas putida W619, complete genomehypothetical protein4e-28123
NC_007912:4661141:466934646693464669819474Saccharophagus degradans 2-40, complete genomehypothetical protein3e-0754.3