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Query: NC_003997:4473973:4493254 Bacillus anthracis str. Ames, complete genome

Start: 4493254, End: 4493565, Length: 312

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:4474000:449328144932814493592312Bacillus anthracis str. A0248, complete genomehypothetical protein9e-43171
NC_012581:4478036:449480544948054495116312Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein9e-43171
NC_007530:4474000:449338144933814493692312Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein9e-43171
NC_005957:4472800:448833244883324488643312Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein5e-42169
NC_011773:4541306:455676045567604557071312Bacillus cereus AH820 chromosome, complete genomehypothetical protein5e-42169
NC_011969:4396000:441570844157084416019312Bacillus cereus Q1 chromosome, complete genomehypothetical protein5e-42169
NC_017208:4662500:467783446778344678145312Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein1e-41167
NC_011772:4606000:462280446228044623115312Bacillus cereus G9842, complete genomehypothetical protein1e-41167
NC_014335:4414052:442724644272464427557312Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein2e-41167
NC_010184:4497473:451801845180184518329312Bacillus weihenstephanensis KBAB4, complete genomePropeptide PepSY amd peptidase M47e-41165