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Query: NC_003997:4473973:4480454 Bacillus anthracis str. Ames, complete genome

Start: 4480454, End: 4480858, Length: 405

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This well studied laboratory strain (Porton isolate) is not virulent due to the loss of the two plasmids, pXO1 and pXO2. Under starvation conditions this group of bacteria initiate a pathway that leads to endospore formation, a process that is thoroughly studied and is a model system for prokaryotic development and differentiation. Spores are highly resistant to heat, cold, dessication, radiation, and disinfectants, and enable the organism to persist in otherwise inhospitable environments. Under more inviting conditions the spores germinate to produce vegetative cells. This organism was the first to be shown to cause disease by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. PA/LF and PA/EF complexes are internalized by host cells where the LF (metalloprotease) and EF (calmodulin-dependent adenylate cyclase) components act. At high levels LF induces cell death and release of the bacterium while EF increases host susceptibility to infection and promotes fluid accumulation in the cells.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:4474000:448048144804814480885405Bacillus anthracis str. A0248, complete genomehypothetical protein2e-73273
NC_012581:4478036:448197844819784482382405Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein2e-73273
NC_007530:4474000:448058144805814480985405Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein2e-73273
NC_005945:4473790:448114344811434481547405Bacillus anthracis str. Sterne, complete genomehypothetical protein2e-73273
NC_011773:4541306:454308745430874543491405Bacillus cereus AH820 chromosome, complete genomehypothetical protein6e-72268
NC_005957:4472800:447458144745814474985405Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein1e-70264
NC_017200:4484399:448971844897184490122405Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein4e-67252
NC_004722:4614442:461839246183924618796405Bacillus cereus ATCC 14579, complete genomehypothetical protein6e-65245
NC_017208:4662500:466251346625134662917405Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein9e-65244
NC_011969:4396000:440252044025204402924405Bacillus cereus Q1 chromosome, complete genomehypothetical protein3e-64243
NC_011725:4636521:464276046427604643164405Bacillus cereus B4264 chromosome, complete genomegroup-specific protein4e-64243
NC_010184:4497473:450281145028114503215405Bacillus weihenstephanensis KBAB4, complete genomehypothetical protein4e-64242
NC_011772:4606000:460729846072984607702405Bacillus cereus G9842, complete genomegroup-specific protein6e-63238