Pre_GI: BLASTP Hits

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Query: NC_003366:981105:981105 Clostridium perfringens str. 13, complete genome

Start: 981105, End: 981845, Length: 741

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008262:904000:910025910025910765741Clostridium perfringens SM101, complete genomehypothetical protein8e-134476
NC_015275:3299923:331544333154433316183741Clostridium lentocellum DSM 5427 chromosome, complete genomehypothetical protein1e-63243
NC_017190:2002718:200770420077042008456753Bacillus amyloliquefaciens LL3 chromosome, complete genomehypothetical protein4e-53207
NC_014551:2057971:206294220629422063694753Bacillus amyloliquefaciens DSM 7, complete genomehypothetical protein4e-53207
NC_008702:2520500:253781425378142538605792Azoarcus sp. BH72, complete genomeconserved hypothetical protein1e-35150
NC_012691:1250385:126161612616161262389774Tolumonas auensis DSM 9187, complete genomehypothetical protein7e-33140
NC_011901:1860887:189688218968821897703822Thioalkalivibrio sulfidophilus HL-EbGr7 chromosome, completehypothetical protein1e-32139
NC_016613:1159980:1178905117890511802421338Vibrio sp. EJY3 chromosome 1, complete sequencehypothetical protein4e-28124
NC_015137:2582467:260576526057652606535771Burkholderia sp. CCGE1001 chromosome 2, complete sequencehypothetical protein3e-22105