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Query: NC_003155:7979050:8000193 Streptomyces avermitilis MA-4680, complete genome

Start: 8000193, End: 8001170, Length: 978

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003888:1751179:175117917511791752132954Streptomyces coelicolor A3(2), complete genomehypothetical protein2e-157555
NC_013729:5497814:550025755002575501219963Kribbella flavida DSM 17836, complete genometranscriptional regulator protein-like protein3e-54212
NC_013093:2471574:248933724893372490320984Actinosynnema mirum DSM 43827, complete genomeputative transcriptional regulator protein4e-49195
NC_013174:1366786:1376222137622213772261005Jonesia denitrificans DSM 20603, complete genomeputative transcriptional regulator protein3e-30132
NC_016799:1268706:127583712758371276814978Corynebacterium diphtheriae 31A chromosome, complete genomehypothetical protein7e-1375.1
NC_016789:1257392:126452312645231265500978Corynebacterium diphtheriae PW8 chromosome, complete genomehypothetical protein6e-1375.1
NC_016800:1243000:124895412489541249931978Corynebacterium diphtheriae BH8 chromosome, complete genomehypothetical protein6e-1375.1
NC_002935:1237585:124679212467921247769978Corynebacterium diphtheriae NCTC 13129, complete genomehypothetical protein9e-1374.7
NC_016783:1239293:124642412464241247401978Corynebacterium diphtheriae INCA 402 chromosome, complete genomehypothetical protein9e-1374.7
NC_016785:1193471:120060212006021201579978Corynebacterium diphtheriae CDCE 8392 chromosome, complete genomehypothetical protein9e-1374.7
NC_016786:1218032:122052412205241221501978Corynebacterium diphtheriae HC01 chromosome, complete genomehypothetical protein9e-1374.7
NC_016787:1207488:120998012099801210957978Corynebacterium diphtheriae HC03 chromosome, complete genomehypothetical protein9e-1374.7
NC_016788:1214026:121996712199671220944978Corynebacterium diphtheriae HC04 chromosome, complete genomehypothetical protein9e-1374.7
NC_016790:1177349:118735711873571188334978Corynebacterium diphtheriae VA01 chromosome, complete genomehypothetical protein9e-1374.7
NC_016802:1212726:121985712198571220834978Corynebacterium diphtheriae HC02 chromosome, complete genomehypothetical protein9e-1374.7
NC_016801:1255611:126561712656171266594978Corynebacterium diphtheriae C7 (beta) chromosome, complete genomehypothetical protein6e-1271.6
NC_015125:1668780:168712716871271688122996Microbacterium testaceum StLB037, complete genomepredicted transcriptional regulator9e-0858.2
NC_015573:1045877:1062081106208110631961116Desulfotomaculum kuznetsovii DSM 6115 chromosome, complete genometranscriptional regulator5e-0755.5
NC_015957:7408466:743208074320807433060981Streptomyces violaceusniger Tu 4113 chromosome, complete genomeregulatory protein DeoR8e-0754.7
NC_015671:1865752:188228018822801883251972Cellvibrio gilvus ATCC 13127 chromosome, complete genomeDeoR family transcriptional regulator3e-0652.8
NC_013729:5982000:598555659855565986518963Kribbella flavida DSM 17836, complete genomeHelix-turn-helix type 11 domain protein9e-0651.2