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Query: NC_003155:6295078:6315925 Streptomyces avermitilis MA-4680, complete genome

Start: 6315925, End: 6316416, Length: 492

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_021177:2766910:276801327680132768495483Streptomyces fulvissimus DSM 40593, complete genomeUPF0303 DUF336 domain containing protein4e-59226
NC_015732:140087:142660142660143139480Spirochaeta caldaria DSM 7334 chromosome, complete genomehypothetical protein7e-34142
NC_008541:2063218:208351120835112084059549Arthrobacter sp. FB24 chromosome 1, complete sequenceprotein of unknown function DUF3366e-24109
NC_016628:1190366:119140311914031191873471Vibrio furnissii NCTC 11218 chromosome 2, complete sequencehypothetical protein4e-21100
NC_014103:2635695:265796826579682658441474Bacillus megaterium DSM319 chromosome, complete genomehypothetical protein2e-1994.7
NC_012587:3177583:320041032004103200907498Rhizobium sp. NGR234, complete genomehypothetical protein4e-1993.6
NC_014019:2661000:267856226785622679035474Bacillus megaterium QM B1551 chromosome, complete genomehypothetical protein3e-1890.9
NC_015152:1602412:160746316074631607957495Spirochaeta sp. Buddy chromosome, complete genomehypothetical protein3e-1684
NC_010551:1462827:148275714827571483263507Burkholderia ambifaria MC40-6 chromosome 1, complete sequenceprotein of unknown function DUF3363e-1271.2