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Query: NC_003155:590500:605005 Streptomyces avermitilis MA-4680, complete genome

Start: 605005, End: 605373, Length: 369

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003155:5616000:563159856315985631939342Streptomyces avermitilis MA-4680, complete genomeanti-sigma factor antagonist5e-0959.7
NC_016114:3938721:395672339567233957076354Streptomyces flavogriseus ATCC 33331 chromosome, complete genomeanti-sigma-factor antagonist7e-0959.3
NC_010572:3878660:388229938822993882652354Streptomyces griseus subsp. griseus NBRC 13350, complete genomeputative anti-sigma factor antagonist8e-0958.9
NC_013510:3065000:308423830842383084558321Thermomonospora curvata DSM 43183, complete genomeanti-sigma-factor antagonist9e-0958.9
NC_013595:480000:498355498355498705351Streptosporangium roseum DSM 43021, complete genomeputative anti-anti-sigma regulatory factor4e-0856.6
NC_016047:637778:638847638847639176330Bacillus subtilis subsp. spizizenii TU-B-10 chromosome, completeanti-sigma-B factor antagonist5e-0753.1
NC_004193:375416:655040655040655372333Oceanobacillus iheyensis HTE831, complete genomepositive regulator of sigma-B activity5e-0753.1
NC_014219:567033:568111568111568440330Bacillus selenitireducens MLS10 chromosome, complete genomeanti-sigma-factor antagonist7e-0752.8
NC_013501:1691532:169470316947031695074372Rhodothermus marinus DSM 4252, complete genomeanti-sigma-factor antagonist9e-0752.4
NC_011898:426951:451241451241451558318Clostridium cellulolyticum H10, complete genomeanti-sigma-factor antagonist9e-0752.4
NC_014165:27246:439594395944309351Thermobispora bispora DSM 43833 chromosome, complete genomeanti-sigma-factor antagonist8e-0752.4
NC_020410:495184:495184495184495513330Bacillus amyloliquefaciens subsp. plantarum UCMB5036 completeanti-anti-sigma factor (antagonist of RsbW)2e-0651.2
NC_019842:484933:484607484607484936330Bacillus amyloliquefaciens subsp. plantarum AS43.3 chromosome,anti-sigma B factor antagonist2e-0651.2
NC_009725:496443:496443496443496772330Bacillus amyloliquefaciens FZB42, complete genomeRsbV2e-0651.2
NC_014479:509919:509919509919510248330Bacillus subtilis subsp. spizizenii str. W23 chromosome, completeanti-anti-sigma factor (antagonist of RsbW)2e-0651.2
NC_004193:375416:375416375416675301299886Oceanobacillus iheyensis HTE831, complete genome5e-0650.1