Pre_GI: BLASTP Hits

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Query: NC_003155:5443230:5459306 Streptomyces avermitilis MA-4680, complete genome

Start: 5459306, End: 5460319, Length: 1014

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013929:4807910:480791048079104808860951Streptomyces scabiei 87.22 chromosome, complete genomehypothetical protein1e-91336
NC_015953:3456535:346392834639283464851924Streptomyces sp. SirexAA-E chromosome, complete genomehypothetical protein3e-75282
NC_010572:4024810:402882140288214029798978Streptomyces griseus subsp. griseus NBRC 13350, complete genomehypothetical protein4e-75281
NC_018750:3741581:375539637553963756307912Streptomyces venezuelae ATCC 10712, complete genomeputative integral membrane protein7e-73274
NC_016111:3486000:349468834946883495452765Streptomyces cattleya NRRL 8057, complete genomeIntegral membrane protein (fragment)2e-68259
NC_016109:4241591:424256842425684243560993Kitasatospora setae KM-6054, complete genomehypothetical protein2e-39163