Pre_GI: BLASTP Hits

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Query: NC_003155:4592000:4594875 Streptomyces avermitilis MA-4680, complete genome

Start: 4594875, End: 4595906, Length: 1032

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008596:1302000:132423813242381324906669Mycobacterium smegmatis str. MC2 155, complete genomehypothetical protein1e-0964.3
NC_016111:2402891:2412938241293824142991362Streptomyces cattleya NRRL 8057, complete genomehypothetical protein1e-0964.3
NC_017955:4075804:410062941006294101399771Modestobacter marinus, complete genomehypothetical protein2e-1583.6
NC_013729:4978401:499195749919574992937981Kribbella flavida DSM 17836, complete genomehypothetical protein8e-44177
NC_018750:2118907:2126151212615121274851335Streptomyces venezuelae ATCC 10712, complete genomehypothetical protein6e-0962
NC_019974:1184871:1248465124846512498831419Natronococcus occultus SP4, complete genomeputative restriction endonuclease2e-0860.5