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Query: NC_003155:3095123:3118702 Streptomyces avermitilis MA-4680, complete genome

Start: 3118702, End: 3121134, Length: 2433

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003888:6233478:6233478623347862367293252Streptomyces coelicolor A3(2), complete genomehypothetical protein2e-167590
NC_014165:92500:9296592965948841920Thermobispora bispora DSM 43833 chromosome, complete genomechromosome partitioning-like ATPase1e-61238
NC_014211:439611:4396114396114417072097Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111 plasmidATPase involved in chromosome partitioning-like protein3e-61237
NC_007333:2674596:2691052269105226920921041Thermobifida fusca YX, complete genomehypothetical protein2e-42174
NC_015145:3236445:3241258324125832426011344Arthrobacter phenanthrenivorans Sphe3 chromosome, complete genomeATPase involved in chromosome partitioning1e-31139
NC_011886:3274048:3284306328430632855561251Arthrobacter chlorophenolicus A6, complete genomehypothetical protein6e-30133
NC_007333:537292:5372925372925407743483Thermobifida fusca YX, complete genomesimilar to ATPase involved in chromosome partitioning5e-27123
NC_013510:675368:6963846963846980181635Thermomonospora curvata DSM 43183, complete genomeATPase involved in chromosome partitioning-like protein7e-1893.2