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Query: NC_003155:3095123:3099241 Streptomyces avermitilis MA-4680, complete genome

Start: 3099241, End: 3099561, Length: 321

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003888:6233478:624393862439386244234297Streptomyces coelicolor A3(2), complete genomeregulator, BldB4e-43172
NC_015957:1968587:197046919704691970699231Streptomyces violaceusniger Tu 4113 chromosome, complete genomehypothetical protein1e-26118
NC_008278:6885254:690709169070916907285195Frankia alni ACN14a, complete genomePutative regulator2e-0857.8
NC_006361:498305:507996507996508202207Nocardia farcinica IFM 10152, complete genomehypothetical protein3e-0857
NC_007777:461500:470346470346470555210Frankia sp. CcI3, complete genomeprotein of unknown function DUF3972e-0754.3
NC_017093:8518961:852422085242208524456237Actinoplanes missouriensis 431, complete genomehypothetical protein6e-0752.8
NC_010572:82000:932859328593518234Streptomyces griseus subsp. griseus NBRC 13350, complete genomeputative regulatory protein3e-0650.4