Pre_GI: BLASTN Hits

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Query: NC_009697:3753527 Clostridium botulinum A str. ATCC 19397 chromosome, complete

Start: 3753527, End: 3771864, Length: 18338

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A ATCC 19397 (NCTC 4587, NCTC 7272) is a stock, type A toxin-producing, laboratory strain of known toxicity. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_010516:3845942*3845942386860822667Clostridium botulinum B1 str. Okra, complete genome04544BLASTN svgBLASTP svg
NC_020291:117983*11798315068032698Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome3e-33151BLASTN svgBLASTP svg
NC_009922:2850320*2850320287198821669Alkaliphilus oremlandii OhILAs, complete genome7e-22113BLASTN svgBLASTP svg
NC_008262:2649289*2649289270467655388Clostridium perfringens SM101, complete genome1e-20109BLASTN svgBLASTP svg
NC_019978:91483*9148311073919257Halobacteroides halobius DSM 5150, complete genome4e-1797.6BLASTN svgBLASTP svg
NC_014614:554949*55494957879923851Clostridium sticklandii, complete genome2e-1695.6BLASTN svgBLASTP svg
NC_010723:173280*17328022135248073Clostridium botulinum E3 str. Alaska E43, complete genome9e-1279.8BLASTN svgBLASTP svg
NS_000191:1037899*1037899106009922201Uncultured Termite group 1 bacterium phylotype Rs-D17, complete1e-0765.9BLASTN svgBLASTP svg
NC_011899:2286884*2286884231116224279Halothermothrix orenii H 168, complete genome1e-0765.9BLASTN svgBLASTP svg
NC_014393:19016881901688192179720110Clostridium cellulovorans 743B chromosome, complete genome5e-0763.9BLASTN svgBLASTP svg