Pre_GI: BLASTP Hits

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Query: NC_018939:1044000:1044570 Helicobacter pylori 26695 chromosome, complete genome

Start: 1044570, End: 1044872, Length: 303

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_000915:1044000:104455210445521044854303Helicobacter pylori 26695, complete genomeconserved hypothetical secreted protein3e-43173
NC_017367:278916:2812252812252822801056Helicobacter pylori F57, complete genomehypothetical protein1e-39161
NC_012973:967380:967380967380967676297Helicobacter pylori B38 chromosome, complete genomemetallopeptidase5e-36149
NC_008229:1149480:1170154117015411711971044Helicobacter acinonychis str. Sheeba, complete genomezinc metalloprotease1e-31134
NC_009802:1077926:1077926107792610790351110Campylobacter concisus 13826, complete genomeRIP metalloprotease RseP4e-1683.2
NC_009714:534015:5522985522985534101113Campylobacter hominis ATCC BAA-381, complete genomeRIP metalloprotease RseP1e-1581.6
NC_009715:905134:9207819207819218931113Campylobacter curvus 525.92 chromosome, complete genomeRIP metalloprotease RseP4e-1373.6
NC_020291:1464500:1465751146575114667731023Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeRIP metalloprotease RasP1e-1168.2
NC_015711:4811349:4829488482948848311191632Myxococcus fulvus HW-1 chromosome, complete genomeM50A family peptidase4e-1167
NC_017294:758992:7701277701277711671041Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomeRIP metalloprotease RseP9e-1165.5
NC_014328:1405484:1407858140785814088681011Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative membrane-associated metalloprotease1e-1065.5
NC_011126:922182:9364389364389377541317Hydrogenobaculum sp. Y04AAS1, complete genomemembrane-associated zinc metalloprotease1e-1065.1
NC_020411:905335:9216839216839229991317Hydrogenobaculum sp. HO, complete genomemembrane-associated zinc metalloprotease3e-1063.9
NC_015587:905255:9216039216039229191317Hydrogenobaculum sp. SHO chromosome, complete genomemembrane-associated zinc metalloprotease3e-1063.9
NC_015557:905145:9214939214939228091317Hydrogenobaculum sp. 3684 chromosome, complete genomemembrane-associated zinc metalloprotease3e-1063.9
NC_010673:113133:1158111158111170941284Borrelia hermsii DAH, complete genomemembrane metalloprotease4e-1063.5
NC_011830:3904034:3933352393335239344161065Desulfitobacterium hafniense DCB-2, complete genomemembrane-associated zinc metalloprotease4e-1063.5
NC_012563:2721658:2733645273364527346551011Clostridium botulinum A2 str. Kyoto, complete genomeRIP metalloprotease RseP4e-1063.5
NC_011898:513835:5138355138355151211287Clostridium cellulolyticum H10, complete genomemembrane-associated zinc metalloprotease4e-1063.5
NC_012658:2584355:2617261261726126182711011Clostridium botulinum Ba4 str. 657 chromosome, complete genomeRIP metalloprotease RseP4e-1063.5
NC_007907:2879568:2904558290455829056491092Desulfitobacterium hafniense Y51, complete genomehypothetical protein5e-1063.2
NC_011244:94756:1280441280441293241281Borrelia recurrentis A1, complete genomezinc protease, putative8e-1062.4
NC_009655:2148433:2166730216673021680581329Actinobacillus succinogenes 130Z chromosome, complete genomeputative membrane-associated zinc metalloprotease1e-0962
NC_008710:108057:1155761155761168591284Borrelia turicatae 91E135, complete genomemembrane metalloprotease1e-0962
NC_011296:229494:2284332284332294971065Thermodesulfovibrio yellowstonii DSM 11347, complete genomemembrane-associated zinc metalloprotease, putative1e-0961.6
NC_009718:1024000:1039513103951310410001488Fervidobacterium nodosum Rt17-B1, complete genomeputative membrane-associated zinc metalloprotease3e-0960.8
NC_015064:1268223:1278995127899512803771383Acidobacterium sp. MP5ACTX9 chromosome, complete genomemembrane-associated zinc metalloprotease4e-0960.1
NC_010003:2134878:2150405215040521519281524Petrotoga mobilis SJ95, complete genomemembrane-associated zinc metalloprotease3e-0857.4
NC_017095:1333810:1343412134341213449021491Fervidobacterium pennivorans DSM 9078 chromosome, complete genomeputative membrane-associated Zn-dependent protease3e-0857.4
NC_014752:131994:1319941319941333341341Neisseria lactamica ST-640, complete genomeinner membrane protease4e-0856.6
NC_017096:779550:7938737938737949071035Caldisericum exile AZM16c01, complete genomeputative M50 family peptidase2e-0754.7
NC_020300:675551:6850896850896862281140Bartonella australis Aust/NH1, complete genomemembrane-associated zinc metalloprotease4e-0753.5
NC_016632:398018:4116874116874130691383Serratia symbiotica str. 'Cinara cedri' chromosome, completeprotease that resides in the inner membrane7e-0752.8
NC_004663:2509433:2517142251714225184971356Bacteroides thetaiotaomicron VPI-5482, complete genomemembrane-associated zinc metalloprotease9e-0752.4
NC_013947:5431741:5437362543736254386481287Stackebrandtia nassauensis DSM 44728 chromosome, complete genomepeptidase M508e-0752.4
NC_017303:1420758:1424089142408914253031215Corynebacterium pseudotuberculosis I19 chromosome, complete genomezinc metalloprotease2e-0650.8
NC_017031:1420738:1424069142406914252831215Corynebacterium pseudotuberculosis P54B96 chromosome, completezinc metalloprotease2e-0650.8
NC_016781:1408235:1424204142420414254181215Corynebacterium pseudotuberculosis 3/99-5 chromosome, completezinc metalloprotease2e-0650.8
NC_014329:1407880:1424266142426614254801215Corynebacterium pseudotuberculosis FRC41 chromosome, completehypothetical protein2e-0650.8
NC_017378:986611:989024989024989329306Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein4e-0650.4
NC_016609:701500:7015377015377028951359Niastella koreensis GR20-10 chromosome, complete genomepeptidase M503e-0650.4
NC_017379:996500:998936998936999049114Helicobacter pylori Puno135 chromosome, complete genomehypothetical protein5e-0649.7
NC_010163:1193237:1205514120551412070611548Acholeplasma laidlawii PG-8A chromosome, complete genomeM50 family metallopeptidase6e-0649.7
NC_017355:997089:100027510002751000415141Helicobacter pylori v225d chromosome, complete genomehypothetical protein6e-0649.7