Pre_GI: BLASTP Hits

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Query: NC_017328:2225418:2226707 Shigella flexneri 2002017 chromosome, complete genome

Start: 2226707, End: 2227513, Length: 807

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002695:2854629:2853628285362828546321005Escherichia coli O157:H7 str. Sakai, complete genomehypothetical protein7e-141499
NC_011741:2239637:2239637223963722406411005Escherichia coli IAI1 chromosome, complete genomeputative (phospho)hydrolase8e-141499
CU928160:2239637:2239637223963722406411005Escherichia coli IAI1 chromosome, complete genomeputative (phospho)hydrolase8e-141499
NC_010473:2267851:2269125226912522701291005Escherichia coli str. K-12 substr. DH10B, complete genomepredicted hydrolase1e-140498
NC_007384:2251792:2251792225179222527961005Shigella sonnei Ss046, complete genomehypothetical protein1e-140498
NC_012759:2069326:2070600207060020716041005Escherichia coli BW2952 chromosome, complete genomeputative hydrolase1e-140498
NC_016822:2341127:2341127234112723421311005Shigella sonnei 53G, complete genomeputative hydrolase1e-140498
CP002185:2347413:2348687234868723496911005Escherichia coli W, complete genomepredicted hydrolase5e-140496
NC_010468:1694729:1713898171389817149021005Escherichia coli ATCC 8739, complete genomeADP-ribosylation/Crystallin J17e-140496
NC_011750:955451:9751829751829761861005Escherichia coli IAI39 chromosome, complete genomeputative (phospho)hydrolase2e-139494
NC_011745:2399313:2399313239931324003171005Escherichia coli ED1a chromosome, complete genomeputative (phospho)hydrolase1e-138492
NC_009792:642881:6589726589726599761005Citrobacter koseri ATCC BAA-895, complete genomehypothetical protein4e-127454
NC_004631:799810:7998107998108008141005Salmonella enterica subsp. enterica serovar Typhi Ty2, completeputative hydrolase8e-115413
NC_003198:2179688:2203122220312222041261005Salmonella enterica subsp. enterica serovar Typhi str. CT18,putative hydrolase8e-115413
NC_016832:799764:7997647997648007681005Salmonella enterica subsp. enterica serovar Typhi str. P-stx-12,hypothetical protein8e-115413
NC_011149:2179592:2203129220312922041331005Salmonella enterica subsp. enterica serovar Agona str. SL483,ADP-ribosylglycohydrolase family protein1e-114412
NC_012125:1632150:1632150163215016331541005Salmonella enterica subsp. enterica serovar Paratyphi C strainglycohydrolase1e-114412
NC_006905:2235607:2260057226005722610611005Salmonella enterica subsp. enterica serovar Choleraesuis strputative glycohydrolase1e-114412
NC_011147:792489:7924897924897934931005Salmonella enterica subsp. enterica serovar Paratyphi A strhydrolase2e-114411
NC_006511:792543:7925437925437935471005Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCCputative hydrolase2e-114411
NC_015968:3053565:3067567306756730685711005Enterobacter asburiae LF7a chromosome, complete genomeADP-ribosylation/Crystallin J15e-113407
NC_014121:3483976:3486555348655534875591005Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, completeputative (phospho)hydrolase2e-111401
NC_020211:2206500:2223078222307822240971020Serratia marcescens WW4, complete genomeputative hydrolase4e-83307
NC_009513:169146:1908671908671919521086Lactobacillus reuteri F275, complete genomeADP-ribosylation/Crystallin J11e-32140
NC_015389:1375315:1379397137939713804071011Coriobacterium glomerans PW2 chromosome, complete genomeADP-ribosylation/Crystallin J18e-24110
NC_013156:226215:228122228122229030909Methanocaldococcus fervens AG86, complete genomeADP-ribosylation/Crystallin J14e-0962
NC_013887:812091:816065816065816970906Methanocaldococcus sp. FS406-22 chromosome, complete genomeADP-ribosylation/Crystallin J13e-0859.3
NC_000909:1123161:112712111271211128026906Methanocaldococcus jannaschii DSM 2661, complete genomedinitrogenase reductase activating glycohydrolase (draG)4e-0858.5
NC_012489:209016:2281522281522292311080Gemmatimonas aurantiaca T-27, complete genomeputative hydrolase4e-0755.5