Pre_GI: BLASTP Hits

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Query: NC_017328:2090679:2102130 Shigella flexneri 2002017 chromosome, complete genome

Start: 2102130, End: 2103773, Length: 1644

Host Lineage: Shigella flexneri; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This organism, along with Shigella sonnei, is the major cause of shigellosis in industrialized countries and is responsible for endemic infections. This genus is named for the Japanese scientist (Shiga) who discovered them in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. Human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, and over 1 million deaths worldwide are attributed to them. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Extremely virulent organisms that require very few cells in order to cause disease. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008258:2045000:2055196205519620568391644Shigella flexneri 5 str. 8401, complete genomeinvasion plasmid antigen01117
NC_004741:2009769:2023205202320520248481644Shigella flexneri 2a str. 2457T, complete genomeinvasion plasmid antigen01116
NC_007613:1038000:1044320104432010459631644Shigella boydii Sb227, complete genomeinvasion plasmid antigen01114
NC_007384:1320287:1346060134606013478111752Shigella sonnei Ss046, complete genomeinvasion plasmid antigen0807
NC_017319:192482:2130342130342147611728Shigella flexneri 2002017 plasmid pSFxv_1, complete sequenceinvasion plasmid antigen, secreted by the Mxi-Spa secretion machinery0737
NC_004851:191709:2131522131522148791728Shigella flexneri 2a str. 301 plasmid pCP301, complete sequenceinvasion plasmid antigen, secreted by the Mxi-Spa secretion machinery0737
NC_007607:87000:1104271104271119711545Shigella dysenteriae Sd197 plasmid pSD1_197, complete sequenceinvasion plasmid antigen, fragment5e-153541
NC_010067:191190:1956651956651977012037Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein5e-99362
NC_015761:1181186:1206110120611012087912682Salmonella bongori NCTC 12419, complete genomeleucine rich-repeat virulence protein5e-99362
NC_010465:804249:8208868208868227331848Yersinia pseudotuberculosis YPIII, complete genomeantigenic leucine-rich repeat protein3e-98359
NC_010067:892729:9070099070099092762268Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein2e-97356
NC_011149:1236689:1237394123739412397242331Salmonella enterica subsp. enterica serovar Agona str. SL483,leucine-rich repeat protein1e-96353
NC_017168:4509918:4522652452265245244691818Yersinia pestis A1122 chromosome, complete genomeputative antigenic leucine-rich repeat protein1e-95350
NC_017154:848500:8665908665908684071818Yersinia pestis D106004 chromosome, complete genomeputative antigenic leucine-rich repeat protein1e-95350
NC_008150:3711953:3727411372741137292281818Yersinia pestis Antiqua, complete genomeputative antigenic leucine-rich repeat protein1e-95350
NC_012125:1517925:1537079153707915392652187Salmonella enterica subsp. enterica serovar Paratyphi C strainhypothetical protein3e-95349
NC_008149:3648139:3666229366622936680551827Yersinia pestis Nepal516, complete genomeantigenic leucine-rich repeat protein3e-95349
NC_012779:1286500:1320729132072913231072379Edwardsiella ictaluri 93-146, complete genomeleucine-rich repeat protein6e-95348
NC_017154:848500:8700868700868719331848Yersinia pestis D106004 chromosome, complete genomeantigenic leucine-rich repeat protein1e-93344
NC_017168:4509918:4526115452611545279951881Yersinia pestis A1122 chromosome, complete genomeputative antigenic leucine-rich repeat protein1e-93344
NC_008149:3648139:3669702366970236715821881Yersinia pestis Nepal516, complete genomeantigenic leucine-rich repeat protein1e-93344
NC_008150:3711953:3723173372317337250531881Yersinia pestis Antiqua, complete genomeputative antigenic leucine-rich repeat protein1e-93344
NC_011205:2462025:2462025246202524643912367Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853hypothetical protein6e-93342
NC_011294:2334979:2334979233497923373452367Salmonella enterica subsp. enterica serovar Enteritidis strsecreted effector protein6e-93342
NC_004631:685357:7045107045107068762367Salmonella enterica subsp. enterica serovar Typhi Ty2, completesecreted effector protein8e-93341
NC_003198:2297837:2297837229783723002032367Salmonella enterica subsp. enterica serovar Typhi str. CT18,secreted effector protein8e-93341
NC_016832:687000:7044647044647068302367Salmonella enterica subsp. enterica serovar Typhi str. P-stx-12,E3 ubiquitin-protein ligase sspH28e-93341
NC_010102:683444:7025587025587049242367Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7,hypothetical protein7e-93341
NC_011083:2375061:2388465238846523908312367Salmonella enterica subsp. enterica serovar Heidelberg str. SL476,leucine-rich repeat protein7e-93341
NC_003197:2327474:2340885234088523432512367Salmonella typhimurium LT2, complete genomeleucine-rich repeat protein7e-93341
NC_016810:2325190:2338601233860123409672367Salmonella enterica subsp. enterica serovar Typhimurium strsecreted effector protein7e-93341
NC_016856:2379027:2392438239243823948042367Salmonella enterica subsp. enterica serovar Typhimurium str. 14028Shypothetical protein7e-93341
NC_016857:2325190:2338601233860123409672367Salmonella enterica subsp. enterica serovar Typhimurium str. ST4/74hypothetical protein7e-93341
NC_016860:2323017:2336428233642823387942367Salmonella enterica subsp. enterica serovar Typhimurium strleucine-rich repeat protein7e-93341
NC_016863:2324293:2340630234063023429962367Salmonella enterica subsp. enterica serovar Typhimurium str. UK-1hypothetical protein7e-93341
NC_017046:2324554:2337965233796523403312367Salmonella enterica subsp. enterica serovar Typhimurium str. 798secreted effector protein7e-93341
NC_011080:2342672:2342672234267223450382367Salmonella enterica subsp. enterica serovar Newport str. SL254,leucine-rich repeat protein1e-92340
NC_016856:1326503:1332051133205113341532103Salmonella enterica subsp. enterica serovar Typhimurium str. 14028SSspH15e-91335
NC_012779:1286500:1318047131804713201612115Edwardsiella ictaluri 93-146, complete genomeSspH18e-90331
NC_010465:804249:8173048173048191721869Yersinia pseudotuberculosis YPIII, complete genomeputative antigenic leucine-rich repeat protein3e-89329
NC_015761:1181186:1188971118897111914122442Salmonella bongori NCTC 12419, complete genomeleucine rich repeat virulence protein4e-82306
NC_004463:2059500:2059723205972320614801758Bradyrhizobium japonicum USDA 110, complete genomehypothetical protein3e-63243
NC_017249:8165826:8165826816582681675711746Bradyrhizobium japonicum USDA 6, complete genomehypothetical protein4e-63242
NC_010067:1782998:1799793179979318009831191Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein1e-44181
NC_010465:804249:819734819734820639906Yersinia pseudotuberculosis YPIII, complete genomeantigenic leucine-rich repeat protein3e-22107
NC_017168:4509918:452467745246774525552876Yersinia pestis A1122 chromosome, complete genomeputative antigenic leucine-rich repeat protein5e-22106
NC_017154:848500:868615868615869490876Yersinia pestis D106004 chromosome, complete genomeputative antigenic leucine-rich repeat protein5e-22106
NC_008149:3648139:366826436682643669139876Yersinia pestis Nepal516, complete genomeantigenic leucine-rich repeat protein5e-22106
NC_008150:3711953:372561637256163726491876Yersinia pestis Antiqua, complete genomeputative antigenic leucine-rich repeat protein5e-22106
NC_006155:3237990:3239683323968332408221140Yersinia pseudotuberculosis IP 32953, complete genomeputative antigenic leucine-rich repeat protein7e-22105
NC_010634:3155741:3157433315743331585721140Yersinia pseudotuberculosis PB1/+, complete genomehypothetical protein7e-22105
NC_010337:98974:1205681205681293908823Heliobacterium modesticaldum Ice1, complete genomemultidomain protein with s-layer homology region, glug motif, ig motif, i-set domain, pkd domain1e-20101
NC_008255:3331613:3332977333297733352682292Cytophaga hutchinsonii ATCC 33406, complete genomeconserved hypothetical protein with multiple leucine-rich repeat domains5e-1686.3
NC_017249:8283701:831025483102548310592339Bradyrhizobium japonicum USDA 6, complete genomehypothetical protein3e-1170.9
NC_004463:1898648:194677319467731947111339Bradyrhizobium japonicum USDA 110, complete genomehypothetical protein3e-1170.9