Pre_GI: BLASTP Hits

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Query: NC_016908:926446:945185 Rickettsia rickettsii str. Colombia chromosome, complete genome

Start: 945185, End: 945637, Length: 453

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016913:232500:234847234847235299453Rickettsia rickettsii str. Brazil chromosome, complete genomehypothetical protein6e-81298
NC_016911:926918:945657945657946109453Rickettsia rickettsii str. Hauke chromosome, complete genomehypothetical protein6e-81298
NC_016909:926000:945294945294945746453Rickettsia rickettsii str. Arizona chromosome, complete genomehypothetical protein6e-81298
NC_009882:915500:934240934240934692453Rickettsia rickettsii str. 'Sheila Smith', complete genomehypothetical protein6e-81298
NC_012633:928500:947096947096947548453Rickettsia africae ESF-5, complete genomehypothetical protein7e-80295
NC_012730:1034115:105437610543761054828453Rickettsia peacockii str. Rustic, complete genomehypothetical protein2e-79293
NC_017065:930985:946879946879947331453Rickettsia slovaca str. D-CWPP chromosome, complete genomehypothetical protein2e-79293
NC_016639:930982:946876946876947328453Rickettsia slovaca 13-B chromosome, complete genomehypothetical protein2e-79293
NC_015866:933500:953376953376953828453Rickettsia heilongjiangensis 054 chromosome, complete genomehypothetical protein4e-78289
NC_017043:376441:394916394916395368453Rickettsia montanensis str. OSU 85-930 chromosome, complete genomehypothetical protein8e-78288
NC_017042:1022112:103847210384721038924453Rickettsia rhipicephali str. 3-7-female6-CWPP chromosome, completehypothetical protein2e-77287
NC_017028:1131896:114942011494201149872453Candidatus Rickettsia amblyommii str. GAT-30V chromosome, completehypothetical protein6e-77285
NC_009900:1011000:102838610283861028838453Rickettsia massiliae MTU5, complete genomehypothetical protein2e-76283
NC_007109:300991:302373302373302825453Rickettsia felis URRWXCal2, complete genomehypothetical protein3e-76283
NC_016931:513662:517258517258517710453Rickettsia massiliae str. AZT80 chromosome, complete genomehypothetical protein3e-76283
NC_017058:497500:499357499357499809453Rickettsia australis str. Cutlack chromosome, complete genomehypothetical protein1e-73274
NC_009883:383500:385275385275385733459Rickettsia bellii OSU 85-389, complete genomehypothetical protein1e-51201
NC_009881:896007:916727916727917056330Rickettsia akari str. Hartford, complete genomehypothetical protein3e-47187
NC_007940:1138324:115656711565671156956390Rickettsia bellii RML369-C, complete genomehypothetical protein6e-33139