Pre_GI: BLASTP Hits

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Query: NC_016768:2521225:2522965 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 2522965, End: 2523312, Length: 348

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012943:2525835:252623525262352526582348Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein5e-62235
NC_014098:1258559:126234812623481262629282Bacillus tusciae DSM 2912 chromosome, complete genomeprotein of unknown function DUF4271e-24111
NC_020054:2033982:205436420543642054645282Fibrella aestuarina BUZ 2 drat genomeprotein of unknown function DUF4274e-24109
NC_005125:2107088:211356121135612113845285Gloeobacter violaceus PCC 7421, complete genomehypothetical protein6e-23106
NC_007645:713930:725911725911726195285Hahella chejuensis KCTC 2396, complete genomehypothetical protein1e-22104
NC_009481:873921:891172891172891456285Synechococcus sp. WH 7803 chromosome, complete genomehypothetical protein9e-1682.4
NC_008319:1601494:161057816105781610862285Synechococcus sp. CC9311, complete genomehypothetical protein3e-1477
NC_007513:438438:453593453593453877285Synechococcus sp. CC9902, complete genomehypothetical protein2e-1374.3
NC_009925:4044691:407193440719344072428495Acaryochloris marina MBIC11017, complete genomehypothetical protein2e-0754.3
NC_005125:2393701:240758024075802408077498Gloeobacter violaceus PCC 7421, complete genomehypothetical protein3e-0753.5
NC_013960:138488:144075144075144860786Nitrosococcus halophilus Nc4 chromosome, complete genomeprotein of unknown function DUF4274e-0650.1