Pre_GI: BLASTP Hits

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Query: NC_016512:1357225:1370173 Propionibacterium acnes TypeIA2 P.acn17 chromosome, complete

Start: 1370173, End: 1370886, Length: 714

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_006085:1379370:139513013951301395843714Propionibacterium acnes KPA171202, complete genomeputative thioesterase9e-135479
NC_016516:1345840:136161813616181362331714Propionibacterium acnes TypeIA2 P.acn33 chromosome, completethioesterase3e-134477
NC_016511:1354949:137072813707281371441714Propionibacterium acnes TypeIA2 P.acn31 chromosome, completethioesterase3e-134477
NC_016111:134444:1447761447761457951020Streptomyces cattleya NRRL 8057, complete genomeThioesterase4e-1271.6
NC_014623:5885903:589343358934335894218786Stigmatella aurantiaca DW4/3-1 chromosome, complete genomethioesterase2e-1066.2
NC_014718:232832:241413241413242126714Burkholderia rhizoxinica HKI 454 chromosome, complete genomeThioesterase8e-0960.8
NC_004578:5336773:533814453381445338905762Pseudomonas syringae pv. tomato str. DC3000, complete genomecoronamic acid synthetase, thioesterase component8e-0960.8
NC_015738:3042000:305498930549893055750762Eggerthella sp. YY7918, complete genomeputative thioesterase involved in non-ribosomal peptide biosynthesis2e-0858.9
NC_012811:1:288722887229672801Methylobacterium extorquens AM1 megaplasmid, complete sequenceputative thioesterase5e-0858.2
NC_012471:1197534:123199012319901232739750Streptococcus equi subsp. equi 4047, complete genomenon-ribosomal peptide synthesis thioesterase type II2e-0756.2
NC_016582:4934854:493781649378164938577762Streptomyces bingchenggensis BCW-1 chromosome, complete genomethioesterase3e-0755.5
NC_017208:2432027:245442824544282455150723Bacillus thuringiensis serovar chinensis CT-43 chromosome, completethioesterase6e-0754.7
NC_017030:3091313:312597631259763126755780Corallococcus coralloides DSM 2259 chromosome, complete genomethioesterase8e-0754.3
NC_015711:7191968:720699172069917207779789Myxococcus fulvus HW-1 chromosome, complete genomeputative thioesterase8e-0753.9
NC_010180:213825:218356218356219078723Bacillus weihenstephanensis KBAB4 plasmid pBWB401, completeOleoyl-(acyl-carrier-protein) hydrolase1e-0653.9