Pre_GI: BLASTP Hits

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Query: NC_015425:198315:214765 Clostridium botulinum BKT015925 chromosome, complete genome

Start: 214765, End: 215166, Length: 402

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008593:196257:210096210096210497402Clostridium novyi NT, complete genomehypothetical protein3e-45180
NC_008262:2598920:264615926461592646560402Clostridium perfringens SM101, complete genomehypothetical protein2e-36150
NC_010674:222016:223125223125223523399Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein3e-36150
NC_010723:223935:225043225043225441399Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein3e-35147
NC_014393:4482896:452749445274944527898405Clostridium cellulovorans 743B chromosome, complete genomehypothetical protein3e-34143
NC_019970:336472:352859352859353254396Thermoanaerobacterium thermosaccharolyticum M0795, complete genomehypothetical protein4e-31133
NC_009012:2100000:210482221048222105217396Clostridium thermocellum ATCC 27405, complete genomehypothetical protein9e-28122
NC_019903:421000:432536432536432928393Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,hypothetical protein4e-25113
NC_007503:2098980:210074221007422101137396Carboxydothermus hydrogenoformans Z-2901, complete genomehypothetical protein6e-24109
NC_015275:3243689:325824032582403258638399Clostridium lentocellum DSM 5427 chromosome, complete genomehypothetical protein5e-1992.8