Pre_GI: BLASTP Hits

Query: NC_011658:4301633:4302449 Bacillus cereus AH187 chromosome, complete genome

Start: 4302449, End: 4302895, Length: 447

Host Lineage: Bacillus cereus; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain was isolated from the vomit of a person having eaten cooked rice by the Public Health Laboratory Service (PHLS), London, UK. The isolate was associated with an emetic outbreak in 1972. This organism is a soil-dwelling opportunistic pathogen that causes food poisoning in infected individuals. The rapid onset is characterized by nausea and vomiting while the late onset is characterized by diarrhea and abdominal pain. The emetic disease is caused by a small stable dodecadepsipeptide cerulide whereas the diarrheal disease is caused by a heat labile enterotoxin. Some strains produce a potent cytotoxin that forms a pore in the membrane of eukaryotic cells and causes necrotic enteritis (death of intestinal epithelial cells) while the unique tripartite membrane lytic toxin hemolysin BL contributes to the diarrheal disease and destructive infections of the eye.