Pre_GI: BLASTP Hits

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Query: NC_011528:647401:653829 Coxiella burnetii CbuK_Q154, complete genome

Start: 653829, End: 654815, Length: 987

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii K Q154 was isolated from a patient with endocarditis and contains the plasmid QpRS. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002971:780502:785938785938786924987Coxiella burnetii RSA 493, complete genomehypothetical protein0674
NC_011527:1113217:112673911267391127725987Coxiella burnetii CbuG_Q212, complete genomemethyltransferase0665
NC_010117:980313:993833993833994714882Coxiella burnetii RSA 331, complete genomeputative methyltransferase2e-171601
NC_008346:800500:815015815015815617603Syntrophomonas wolfei subsp. wolfei str. Goettingen, completehypothetical protein1e-65250
NC_014820:1057826:1060918106091810620901173Cenarchaeum symbiosum A, complete genomeSAM dependent methyltransferase2e-40166
NC_016830:530397:551588551588552316729Pseudomonas fluorescens F113 chromosome, complete genomeSAM-dependent methyltransferase3e-1169.3
NC_015416:1872000:189281718928171893683867Methanosaeta concilii GP-6 chromosome, complete genomemethyltransferase domain family9e-1064.7
NC_014844:762794:772362772362773180819Desulfovibrio aespoeensis Aspo-2 chromosome, complete genometype 11 methyltransferase3e-0963.2
NC_011830:1288984:129762412976241298436813Desulfitobacterium hafniense DCB-2, complete genomeMethyltransferase type 117e-0961.6
NC_016791:3891272:390336139033613904176816Clostridium sp. BNL1100 chromosome, complete genomemethylase involved in ubiquinone/menaquinone biosynthesis2e-0860.1
NC_015660:1869962:188409818840981884898801Geobacillus thermoglucosidasius C56-YS93 chromosome, completetype 11 methyltransferase3e-0859.7
NC_016593:596500:625253625253626047795Geobacillus thermoleovorans CCB_US3_UF5 chromosome, completetype 11 methyltransferase3e-0859.7
NC_006510:591339:616525616525617319795Geobacillus kaustophilus HTA426, complete genomehypothetical protein3e-0859.7
NC_014650:1862165:186521918652191866019801Geobacillus sp. Y4.1MC1 chromosome, complete genometype 11 methyltransferase3e-0859.7
NC_011884:3881568:389205338920533892859807Cyanothece sp. PCC 7425, complete genomeMethyltransferase type 113e-0859.7
NC_010162:7899980:7914986791498679161551170Sorangium cellulosum 'So ce 56', complete genomeputative methyltransferase6e-0858.5
NC_010831:788500:808202808202809005804Chlorobium phaeobacteroides BS1, complete genomeMethyltransferase type 113e-0756.6
NC_016791:3953972:398070439807043981519816Clostridium sp. BNL1100 chromosome, complete genomemethylase involved in ubiquinone/menaquinone biosynthesis3e-0756.2
NC_016751:1979201:199973819997382000439702Marinitoga piezophila KA3 chromosome, complete genomemethylase5e-0755.8
NC_006663:1:100551005510789735Staphylococcus epidermidis RP62A plasmid pSERP, complete sequencemethyltransferase, UbiE/COQ5 family4e-0755.8
NC_009442:908507:927674927674928408735Streptococcus suis 05ZYH33 chromosome, complete genomehypothetical protein4e-0755.8
NC_013173:133466:1503251503251514161092Desulfomicrobium baculatum DSM 4028, complete genomeMethyltransferase type 115e-0755.5
NC_016629:4081500:4089382408938240904521071Desulfovibrio africanus str. Walvis Bay chromosome, completetype 11 methyltransferase7e-0755.1
NC_007907:4714844:473082347308234731635813Desulfitobacterium hafniense Y51, complete genomehypothetical protein8e-0754.7
NC_014328:2467239:248077824807782481515738Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative methyltransferase2e-0653.9
NC_008699:4443000:445735044573504458183834Nocardioides sp. JS614, complete genomeMethyltransferase type 112e-0653.9
NC_014408:682689:695291695291696235945Methanothermobacter marburgensis str. Marburg chromosome, completemethyltransferase2e-0653.5
NC_009706:2673906:269039326903932691133741Clostridium kluyveri DSM 555 chromosome, complete genomemethyltransferase2e-0653.5
NC_011837:2605409:262189626218962622636741Clostridium kluyveri NBRC 12016, complete genomehypothetical protein2e-0653.5
NC_011898:3367457:336745733674573368197741Clostridium cellulolyticum H10, complete genomeMethyltransferase type 112e-0653.5
NC_013206:21288:316933169332505813Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446Methyltransferase type 113e-0653.1
NC_016051:1385490:141399914139991414601603Thermococcus sp. AM4 chromosome, complete genomeUbiE/COQ5 family SAM-dependent methyltransferase3e-0653.1
NC_008380:855246:885045885045885887843Rhizobium leguminosarum bv. viciae 3841, complete genomehypothetical protein4e-0652.4
NC_016804:1679357:1700273170027317013161044Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative methyltransferase7e-0651.6
NC_002945:1680751:1701666170166617027091044Mycobacterium bovis AF2122/97, complete genomemethyltransferase7e-0651.6
NC_008769:1709078:1729994172999417310371044Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative methyltransferase7e-0651.6
NC_012207:1681971:1702887170288717039301044Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative methyltransferase7e-0651.6