Pre_GI: BLASTP Hits

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Query: NC_009697:120117:133328 Clostridium botulinum A str. ATCC 19397 chromosome, complete

Start: 133328, End: 134074, Length: 747

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A ATCC 19397 (NCTC 4587, NCTC 7272) is a stock, type A toxin-producing, laboratory strain of known toxicity. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009698:120119:133330133330134076747Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein4e-129460
NC_009495:128000:140525140525141271747Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein4e-129460
NC_017297:122383:135599135599136345747Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein1e-128458
NC_009699:122000:135334135334136080747Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein1e-128458
NC_012563:122000:134461134461135207747Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein1e-128458
NC_010516:127000:140318140318141064747Clostridium botulinum B1 str. Okra, complete genomehypothetical protein5e-128456
NC_012658:125500:137970137970138716747Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein6e-127453
NC_010520:121077:134312134312135058747Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein1e-125449
NC_007503:1111457:114209611420961142857762Carboxydothermus hydrogenoformans Z-2901, complete genomehypothetical protein2e-84312
NC_015565:2027279:205331520533152054064750Desulfotomaculum carboxydivorans CO-1-SRB chromosome, complete1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase4e-78291
NC_014624:1369642:137785313778531378602750Eubacterium limosum KIST612 chromosome, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase2e-78291
NC_019978:315346:321890321890322657768Halobacteroides halobius DSM 5150, complete genomeNCAIR mutase-like protein5e-78290
NC_011297:1357947:137070513707051371463759Dictyoglomus thermophilum H-6-12, complete genomecircadian phase modifier CpmA3e-71268
NC_011661:1542335:155508715550871555845759Dictyoglomus turgidum DSM 6724, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase8e-71266
NC_015388:1161740:116489911648991165651753Desulfobacca acetoxidans DSM 11109 chromosome, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase1e-67256
NC_016023:1874827:188179318817931882548756Bacillus coagulans 36D1 chromosome, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase4e-64244
NC_014507:1127115:113860211386021139357756Methanoplanus petrolearius DSM 11571 chromosome, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase2e-63242
NC_006510:1995916:200719220071922008001810Geobacillus kaustophilus HTA426, complete genomehypothetical protein7e-63240
NC_014206:1618988:163087216308721631681810Geobacillus sp. C56-T3 chromosome, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase7e-63240
NC_014216:608740:615153615153615908756Desulfurivibrio alkaliphilus AHT2 chromosome, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase3e-53208
NC_007604:1183497:120132712013271202109783Synechococcus elongatus PCC 7942, complete genomecircadian phase modifier CpmA1e-51203
NC_006576:414696:418696418696419478783Synechococcus elongatus PCC 6301, complete genomecircadian phase modifier CpmA1e-51203
NC_015320:1342105:137331213733121374040729Archaeoglobus veneficus SNP6 chromosome, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase3e-44178
NC_009975:1565865:156586515658651566632768Methanococcus maripaludis C6, complete genomeconserved hypothetical protein5e-43174
NC_015574:2322811:232821923282192328974756Methanobacterium sp. SWAN-1 chromosome, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase1e-42173
NC_009634:349204:369651369651370418768Methanococcus vannielii SB chromosome, complete genomehypothetical protein4e-40164
NC_008553:1717000:173707517370751737863789Methanosaeta thermophila PT, complete genomephosphoribosylaminoimidazole carboxylase related protein4e-38158
NC_013156:182896:182121182121182939819Methanocaldococcus fervens AG86, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase4e-38157
NC_014122:939190:942984942984943766783Methanocaldococcus infernus ME chromosome, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase4e-36151
NC_009051:1588060:158806015880601588797738Methanoculleus marisnigri JR1, complete genomeAIR carboxylase6e-36150
NC_009486:1737703:179106917910691791824756Thermotoga petrophila RKU-1 chromosome, complete genomeNCAIR mutase (PurE)-like protein1e-35149
NC_015416:1542202:154376315437631544602840Methanosaeta concilii GP-6 chromosome, complete genomehypothetical protein6e-33140
NC_014002:809816:828170828170828985816Methanohalophilus mahii DSM 5219 chromosome, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase1e-31136
NC_007355:923218:923218923218924024807Methanosarcina barkeri str. fusaro chromosome 1, complete sequenceAIR carboxylase1e-30133
NC_013158:2303000:230415823041582304931774Halorhabdus utahensis DSM 12940, complete genome1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase6e-30130
NC_009615:3818500:383660138366013837107507Parabacteroides distasonis ATCC 8503 chromosome, complete genomephosphoribosylaminoimidazole carboxylase catalytic subunit PurE2e-0653.1
NC_015562:1460124:148780114878011488274474Methanotorris igneus Kol 5 chromosome, complete genomephosphoribosylaminoimidazole carboxylase, catalytic subunit2e-0652.8
NC_019977:728922:729810729810730196387Methanomethylovorans hollandica DSM 15978, complete genomephosphoribosylcarboxyaminoimidazole (NCAIR) mutase2e-0652.8
NC_013156:182896:207982207982208458477Methanocaldococcus fervens AG86, complete genomephosphoribosylaminoimidazole carboxylase, catalytic subunit5e-0651.6