Pre_GI: BLASTP Hits

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Query: NC_009089:873295:899092 Clostridium difficile 630, complete genome

Start: 899092, End: 899871, Length: 780

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017179:805867:834689834689835468780Clostridium difficile BI1, complete genomehistidinol-phosphatase7e-131466
NC_013315:796313:825135825135825914780Clostridium difficile CD196 chromosome, complete genomehistidinol-phosphatase7e-131466
NC_008262:904000:9126639126639145371875Clostridium perfringens SM101, complete genomesensory box protein/histidinol phosphate phosphatase family protein5e-66251
NC_003366:981105:9859459859459878191875Clostridium perfringens str. 13, complete genomehistidinol-phosphatase3e-65248
NC_009725:2784334:278433427843342785146813Bacillus amyloliquefaciens FZB42, complete genomeHisJ2e-56218
NC_009328:2808897:281078728107872811611825Geobacillus thermodenitrificans NG80-2 chromosome, complete genomehistidinol-phosphatase8e-56217
UCMB5137:2418403:241759724175972418406810Bacillus atrophaeus UCMB-5137histidinol-phosphatase6e-54211
CP002207:2452286:245228624522862453095810Bacillus atrophaeus 1942, complete genomehistidinol-phosphatase7e-54210
NC_014639:2452286:245228624522862453095810Bacillus atrophaeus 1942 chromosome, complete genomehistidinol-phosphatase7e-54210
NC_010556:2328303:233108223310822331876795Exiguobacterium sibiricum 255-15, complete genomehistidinol phosphate phosphatase HisJ family4e-50198
NC_018665:2163713:216927821692782170072795Exiguobacterium antarcticum B7 chromosome, complete genomeHistidinol phosphate phosphatase HisJ family3e-49195
NC_014364:394899:464885464885465736852Spirochaeta smaragdinae DSM 11293 chromosome, complete genomehistidinol phosphate phosphatase HisJ family2e-1272.8
NC_014483:195321:204956204956205780825Paenibacillus polymyxa E681 chromosome, complete genomeProbable histidinol-phosphatase (HolPase)3e-1168.9
NC_015519:924000:936205936205937032828Tepidanaerobacter sp. Re1 chromosome, complete genomehistidinol phosphate phosphatase HisJ family1e-0653.5