Pre_GI: BLASTP Hits

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Query: NC_009089:873295:890080 Clostridium difficile 630, complete genome

Start: 890080, End: 892206, Length: 2127

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017179:805867:8256828256828278082127Clostridium difficile BI1, complete genomebifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta01361
NC_013315:796313:8161288161288182542127Clostridium difficile CD196 chromosome, complete genomebifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta01361
NC_013316:796895:8136688136688157942127Clostridium difficile R20291, complete genomeputative carbon monoxide dehydrogenase/acetyl-CoA synthase complex, beta subunit01361
NC_014614:1309203:1328306132830613304322127Clostridium sticklandii, complete genomeCarbon monoxide dehydrogenase/acetyl CoA synthase subunit alpha (Acetyl CoA synthase subunit) (CODH/ACS) (ACS subunit)01056
NC_014328:4073714:4077732407773240798582127Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeCO dehydrogenase/acetyl-CoA synthase complex subunit beta01030
NC_015519:586000:6027136027136048362124Tepidanaerobacter sp. Re1 chromosome, complete genomeCO dehydrogenase/acetyl-CoA synthase complex subunit beta0956
NC_021184:504728:5067775067775089722196Desulfotomaculum gibsoniae DSM 7213, complete genomeCO dehydrogenase/CO-methylating acetyl-CoA synthase complex, beta subunit3e-176619
NC_013887:90929:1096381096381119112274Methanocaldococcus sp. FS406-22 chromosome, complete genomeCO dehydrogenase/acetyl-CoA synthase complex, beta subunit7e-163574
NC_015682:379373:3868723868723891602289Thermodesulfobacterium sp. OPB45 chromosome, complete genomeCO dehydrogenase/acetyl-CoA synthase complex subunit beta1e-162573
NC_015562:1386535:1406335140633514085272193Methanotorris igneus Kol 5 chromosome, complete genomeCO dehydrogenase/acetyl-CoA synthase complex subunit beta1e-153544
NC_009712:1185301:1208795120879512108252031Candidatus Methanoregula boonei 6A8, complete genomebifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta2e-151536
NC_013887:90929:1046931046931061051413Methanocaldococcus sp. FS406-22 chromosome, complete genomeCO dehydrogenase/acetyl-CoA synthase complex, beta subunit4e-107389
NC_013156:182896:1963561963561977621407Methanocaldococcus fervens AG86, complete genomeCO dehydrogenase/acetyl-CoA synthase complex, beta subunit3e-105382
NC_015562:1386535:1401268140126814026621395Methanotorris igneus Kol 5 chromosome, complete genomeCO dehydrogenase/acetyl-CoA synthase complex subunit beta7e-96352
NC_014002:1173561:1181568118156811829651398Methanohalophilus mahii DSM 5219 chromosome, complete genomeacetyl-CoA decarbonylase/synthase beta subunit6e-94345
NC_018876:2760000:2770017277001727714381422Methanolobus psychrophilus R15 chromosome, complete genomeacetyl-CoA decarbonylase/synthase complex subunit beta4e-90332
NC_009634:349204:3592283592283606071380Methanococcus vannielii SB chromosome, complete genomeacetyl-CoA decarbonylase/synthase complex subunit beta8e-89328
NC_003552:4714457:4745282474528247466941413Methanosarcina acetivorans C2A, complete genomeacetyl-CoA decarbonylase/synthase complex subunit beta2e-88327
NC_003552:1202909:1209881120988112112901410Methanosarcina acetivorans C2A, complete genomeacetyl-CoA decarbonylase/synthase complex subunit beta4e-88326
NC_015574:2021300:2027731202773120291281398Methanobacterium sp. SWAN-1 chromosome, complete genomeacetyl-CoA decarbonylase/synthase complex subunit beta4e-88326
NC_013849:627811:6369696369696385461578Ferroglobus placidus DSM 10642 chromosome, complete genomeCO dehydrogenase/acetyl-CoA synthase complex, beta subunit9e-88325
NC_005791:961500:9681289681289695011374Methanococcus maripaludis S2, complete genomeacetyl-CoA decarbonylase/synthase complex subunit beta9e-88325
NC_009975:1565865:1574780157478015761531374Methanococcus maripaludis C6, complete genomeCO dehydrogenase/acetyl-CoA synthase complex, beta subunit6e-88325
NC_015216:434752:4450204450204464261407Methanobacterium sp. AL-21 chromosome, complete genomeCO dehydrogenase/acetyl-CoA synthase complex subunit beta3e-87323
NC_015320:967701:9765149765149780191506Archaeoglobus veneficus SNP6 chromosome, complete genomeCO dehydrogenase/acetyl-CoA synthase complex subunit beta1e-85318
NC_003901:815389:8228978228978243061410Methanosarcina mazei Go1, complete genomeacetyl-CoA decarbonylase/synthase complex subunit beta1e-85317
NC_003901:2479613:2487851248785124892631413Methanosarcina mazei Go1, complete genomeacetyl-CoA decarbonylase/synthase complex subunit beta9e-85315
NC_015416:1645419:1657341165734116587501410Methanosaeta concilii GP-6 chromosome, complete genomeCO dehydrogenase/acetyl-CoA synthase complex subunit beta1e-77291