Pre_GI: BLASTP Hits

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Query: NC_009089:873295:881326 Clostridium difficile 630, complete genome

Start: 881326, End: 881958, Length: 633

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017179:805867:816928816928817560633Clostridium difficile BI1, complete genomemethenyltetrahydrofolate cyclohydrolase5e-99360
NC_013315:796313:807374807374808006633Clostridium difficile CD196 chromosome, complete genomemethenyltetrahydrofolate cyclohydrolase5e-99360
NC_013316:796895:804914804914805546633Clostridium difficile R20291, complete genomemethenyltetrahydrofolate cyclohydrolase5e-99360
NC_014328:4073714:408803740880374088669633Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeformyltetrahydrofolate cyclohydrolase5e-70263
NC_015519:586000:594135594135594764630Tepidanaerobacter sp. Re1 chromosome, complete genomemethenyltetrahydrofolate cyclohydrolase6e-51200
NC_007503:1680513:168490316849031685535633Carboxydothermus hydrogenoformans Z-2901, complete genomemethenyltetrahydrofolate cyclohydrolase9e-48189
NC_014614:1309203:132054013205401321196657Clostridium sticklandii, complete genomeMethenyltetrahydrofolate cyclohydrolase4e-47187
NC_015578:1038588:104039010403901041019630Treponema primitia ZAS-2 chromosome, complete genomemethenyl-THF cyclohydrolase1e-39162
NC_014376:1217000:123591012359101236536627Clostridium saccharolyticum WM1 chromosome, complete genomeFormiminotransferase-cyclodeaminase2e-32138
NC_007296:1762000:176965717696571770283627Streptococcus pyogenes MGAS6180, complete genomeformiminotetrahydrofolate cyclodeaminase5e-30130
NC_015738:2773552:277447027744702775084615Eggerthella sp. YY7918, complete genomemethenyl tetrahydrofolate cyclohydrolase5e-27120
NC_010729:1818500:183215918321591832788630Porphyromonas gingivalis ATCC 33277, complete genomeputative methenyltetrahydrofolate cyclohydrolase2e-26118
NC_002950:353549:359175359175359804630Porphyromonas gingivalis W83, complete genomehypothetical protein2e-26118
NC_015571:1495286:149737614973761498005630Porphyromonas gingivalis TDC60, complete genomeputative methenyltetrahydrofolate cyclohydrolase8e-26116
NC_014328:2326930:233523623352362335874639Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeformiminotransferase-cyclodeaminase1e-2099.8
NC_009615:4425500:445667044566704457293624Parabacteroides distasonis ATCC 8503 chromosome, complete genomeformiminotransferase-cyclodeaminase2e-2099.4
NC_002689:78297:919339193392547615Thermoplasma volcanium GSS1, complete genomeFormiminotetrahydrofolate cyclodeaminase4e-1891.3
NC_017095:1461520:147554114755411476173633Fervidobacterium pennivorans DSM 9078 chromosome, complete genomemethenyltetrahydrofolate cyclohydrolase2e-1789
NC_011653:1728000:173107717310771731700624Thermosipho africanus TCF52B, complete genomemethenyltetrahydrofolate cyclohydrolase3e-1788.6
NC_019908:2496149:252146225214622522100639Brachyspira pilosicoli P43/6/78 chromosome, complete genomeformiminotransferase cyclodeaminase5e-1580.9
NC_009617:1165539:118662211866221187272651Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeformiminotransferase-cyclodeaminase8e-1580.1
NC_012108:4937000:4951635495163549532511617Desulfobacterium autotrophicum HRM2, complete genomeFtcD25e-1477.8
NC_008262:2025699:202793420279342028569636Clostridium perfringens SM101, complete genomemethenyltetrahydrofolate cyclohydrolase2e-1272.8
NC_009828:469778:474348474348474986639Thermotoga lettingae TMO, complete genomeFormiminotransferase-cyclodeaminase2e-1272
NC_009921:4948500:497299449729944973800807Frankia sp. EAN1pec, complete genomeFormiminotransferase-cyclodeaminase5e-1167.8
NC_012526:2431388:243138824313882432008621Deinococcus deserti VCD115, complete genomeputative methenyltetrahydrofolate cyclohydrolase4e-1064.7