Pre_GI: BLASTP Hits

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Query: NC_009089:428075:447677 Clostridium difficile 630, complete genome

Start: 447677, End: 448180, Length: 504

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009089:3935500:395791339579133958416504Clostridium difficile 630, complete genomeconjugative transposon protein2e-77287
NC_017179:4023139:403755540375554038058504Clostridium difficile BI1, complete genomeconjugative transposon protein1e-63241
NC_013315:4015119:402953540295354030038504Clostridium difficile CD196 chromosome, complete genomeconjugative transposon protein1e-63241
NC_013316:4095905:411032141103214110824504Clostridium difficile R20291, complete genomeconjugative tranposon protein1e-63241
NC_009089:581655:58476958476960656321795Clostridium difficile 630, complete genome1e-49195
NC_009089:581655:589599589599590096498Clostridium difficile 630, complete genomeconjugative transposon protein2e-45181
NC_016630:1247251:126031312603131260810498Filifactor alocis ATCC 35896 chromosome, complete genomeantirestriction protein (ArdA)2e-44178
NC_013895:1332832:136497913649791365473495Clostridiales genomosp. BVAB3 str. UPII9-5 chromosome, completeantirestriction protein2e-44177
NC_009089:3889811:390472539047253905222498Clostridium difficile 630, complete genomeputative conjugative transposon antirestriction protein6e-40162
NC_017347:424500:439303439303439803501Staphylococcus aureus subsp. aureus T0131 chromosome, completeConjugative transposon protein5e-35146
NC_017341:428500:442965442965443465501Staphylococcus aureus subsp. aureus str. JKD6008 chromosome,putative antirestriction protein5e-35146
NC_002758:434462:449748449748450248501Staphylococcus aureus subsp. aureus Mu50, complete genomehypothetical protein5e-35146
NC_004668:2198027:225899622589962259496501Enterococcus faecalis V583, complete genomehypothetical protein5e-31133
NC_017179:4023139:403704240370424037539498Clostridium difficile BI1, complete genomeconjugative transposon protein5e-1786.7
NC_013315:4015119:402902240290224029519498Clostridium difficile CD196 chromosome, complete genomeconjugative transposon protein5e-1786.7
NC_013316:4095905:410980841098084110305498Clostridium difficile R20291, complete genomeconjugative transposon protein5e-1786.7
NC_010995:1417329:142651614265161427301786Cellvibrio japonicus Ueda107, complete genomeantirestriction protein family protein1e-1479.3
NC_016630:434500:4368074368074382401434Filifactor alocis ATCC 35896 chromosome, complete genomeantirestriction protein (ArdA)4e-1270.9
NC_009706:238160:260396260396261100705Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein1e-0962
NC_011837:238160:260396260396261100705Clostridium kluyveri NBRC 12016, complete genomehypothetical protein1e-0962
NC_014828:1905479:190547919054791906192714Ethanoligenens harbinense YUAN-3 chromosome, complete genomeAntirestriction ArdA family protein8e-0959.7
NC_009439:3770282:378958037895803790092513Pseudomonas mendocina ymp, complete genome1e-0858.9
NC_009089:3935500:395843439584343958937504Clostridium difficile 630, complete genomeconjugative transposon protein2e-0858.2
NC_020418:116500:147805147805148389585Morganella morganii subsp. morganii KT, complete genomehypothetical protein1e-0652.4